A Tumor-Specific Cascade Amplification Drug Release Nanoparticle for Overcoming Multidrug Resistance in Cancers

被引：300

作者：

Ye, Mingzhou ^{[1
,2
]}

Han, Yuxin ^{[1
]}

Tang, Jianbin ^{[1
]}

Piao, Ying ^{[1
]}

Liu, Xiangrui ^{[1
]}

Zhou, Zhuxian ^{[1
]}

Gao, Jianqing ^{[2
]}

Rao, Jianghong ^{[3
]}

Shen, Youqing ^{[1
]}

机构：

[1] Zhejiang Univ, Key Lab Biomass Chem Engn, Minist Educ, Ctr Bionanoengn,Coll Chem & Biol Engn, Hangzhou 310027, Zhejiang, Peoples R China

[2] Zhejiang Univ, Inst Pharmaceut, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China

[3] Stanford Univ, Sch Med, Mol Imaging Program, Stanford Dept Radiol, Stanford, CA 94305 USA

来源：

ADVANCED MATERIALS | 2017年 / 29卷 / 38期

基金：

中国国家自然科学基金;

关键词：

-lapachone; anticancer prodrug; cascade amplification drug release; drug delivery; multidrug resistance; BETA-LAPACHONE; HYDROGEN-PEROXIDE; OXIDATIVE STRESS; P-GLYCOPROTEIN; DELIVERY; APOPTOSIS; DOXORUBICIN; NANOTHERAPEUTICS; NANOCARRIERS; ACTIVATION;

D O I：

10.1002/adma.201702342

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A cascade amplification release nanoparticle (CARN) is constructed by the coencapsulation of -lapachone and a reactive-oxygen-species (ROS)-responsive doxorubicin (DOX) prodrug, BDOX, in polymeric nanoparticles. Releasing -lapachone first from the CARNs selectively increases the ROS level in cancer cells via NAD(P)H:quinone oxidoreductase-1 (NQO1) catalysis, which induces the cascade amplification release of DOX and overcomes multidrug resistance (MDR) in cancer cells, producing a remarkably improved therapeutic efficacy against MDR tumors with minimal side effects.

引用

页数：10

共 48 条

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