New developments in the treatment of opioid-induced gastrointestinal symptoms

被引：12

作者：

Pannemans, Jasper ^{[1
]}

Vanuytsel, Tim ^{[1
]}

Tack, Jan ^{[1
]}

机构：

[1] KU Leuven Univ, Dept Chron Dis Metab & Ageing, Translat Res Ctr Gastrointestinal Disorders TARGI, Leuven, Belgium

来源：

UNITED EUROPEAN GASTROENTEROLOGY JOURNAL | 2018年 / 6卷 / 08期

关键词：

Laxative; opioid-induced constipation; peripherally acting mu-opioid receptor blocker; review; treatment; INDUCED BOWEL DYSFUNCTION; PROLONGED-RELEASE OXYCODONE; PLACEBO-CONTROLLED TRIAL; CONTROLLED PHASE-3 TRIAL; CHRONIC NONCANCER PAIN; INDUCED CONSTIPATION; DOUBLE-BLIND; SUBCUTANEOUS METHYLNALTREXONE; NONMALIGNANT PAIN; EFFICACY;

D O I：

10.1177/2050640618796748

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Chronic pain affects a large part of the global population, leading to an increase of opioid use. Opioid-induced constipation (OIC), a highly prevalent adverse effect of opioid use, has a major impact on patients' quality of life. Thanks to the introduction of new drugs for chronic constipation, which can also be used in OIC, and the development of peripherally acting mu-opioid receptor blockers, specifically for use in OIC, therapeutic options have seen major development. This review summarises current and emerging treatment options for OIC based on an extensive bibliographical search. Efficacy data for laxatives, lubiprostone, prucalopride, linaclotide, oxycodone/naloxone combinations, methylnaltrexone, alvimopan, naloxegol, naldemedine, axelopran, and bevenopran in OIC are summarised.

引用

页码：1126 / 1135

页数：10

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