A Mathematical Model of Regenerative Axon Growing along Glial Scar after Spinal Cord Injury

被引:5
|
作者
Chen, Xuning [1 ]
Zhu, Weiping [1 ]
机构
[1] Shanghai Univ, Shanghai Inst Appl Math & Mech, Shanghai 200072, Peoples R China
关键词
CHONDROITIN SULFATE PROTEOGLYCANS; MOLECULAR GRADIENTS; LOCOMOTOR RECOVERY; NERVOUS-SYSTEM; NOGO RECEPTOR; GUIDANCE; MECHANISMS; GROWTH; INHIBITOR; DIFFUSION;
D O I
10.1155/2016/3030454
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
A major factor in the failure of central nervous system (CNS) axon regeneration is the formation of glial scar after the injury of CNS. Glial scar generates a dense barrier which the regenerative axons cannot easily pass through or by. In this paper, a mathematical model was established to explore how the regenerative axons grow along the surface of glial scar or bypass the glial scar. This mathematical model was constructed based on the spinal cord injury (SCI) repair experiments by transplanting Schwann cells as bridge over the glial scar. The Lattice Boltzmann Method (LBM) was used in this model for three-dimensional numerical simulation. The advantage of this model is that it provides a parallel and easily implemented algorithm and has the capability of handling complicated boundaries. Using the simulated data, two significant conclusions were made in this study: (1) the levels of inhibitory factors on the surface of the glial scar are the main factors affecting axon elongation and (2) when the inhibitory factor levels on the surface of the glial scar remain constant, the longitudinal size of the glial scar has greater influence on the average rate of axon growth than the transverse size. These results will provide theoretical guidance and reference for researchers to design efficient experiments.
引用
收藏
页数:9
相关论文
共 50 条
  • [21] Role of Telomerase Reverse Transcriptase in Glial Scar Formation After Spinal Cord Injury in Rats
    Xu Tao
    Yang Ming-kun
    Sheng Wei-bin
    Guo Hai-long
    Kan Rui
    Tu Lai-yong
    NEUROCHEMICAL RESEARCH, 2013, 38 (09) : 1914 - 1920
  • [22] Manipulating the glial scar: Chondroitinase ABC as a therapy for spinal cord injury
    Bradbury, Elizabeth J.
    Carter, Lucy M.
    BRAIN RESEARCH BULLETIN, 2011, 84 (4-5) : 306 - 316
  • [23] The relationship between macrophage polarization and glial scar formation in mouse model of spinal cord injury
    Yang, Mingkun
    Dang, Xiaojian
    Gao, Kai
    Li, Zhou
    Liu, Minyi
    He, Kunlin
    NEUROENDOCRINOLOGY LETTERS, 2020, 41 (7-8) : 385 - 391
  • [24] Glial scar survives until the chronic phase by recruiting scar-forming astrocytes after spinal cord injury
    Tamaru, Tetsuya
    Kobayakawa, Kazu
    Saiwai, Hirokazu
    Konno, Daijiro
    Kijima, Ken
    Yoshizaki, Shingo
    Hata, Kazuhiro
    Iura, Hirotaka
    Ono, Gentaro
    Haruta, Yohei
    Kitade, Kazuki
    Iida, Kei-Ichiro
    Kawaguchi, Ken-Ichi
    Matsumoto, Yoshihiro
    Kubota, Kensuke
    Maeda, Takeshi
    Okada, Seiji
    Nakashima, Yasuharu
    EXPERIMENTAL NEUROLOGY, 2023, 359
  • [25] DIRECTING AXON REGENERATION AFTER SPINAL CORD INJURY
    Jin, Ying
    Smith, George
    JOURNAL OF NEUROTRAUMA, 2009, 26 (08) : A9 - A9
  • [26] Dissecting the Dual Role of the Glial Scar and Scar-Forming Astrocytes in Spinal Cord Injury
    Yang, Tuo
    Dai, YuJuan
    Chen, Gang
    Cui, ShuSen
    FRONTIERS IN CELLULAR NEUROSCIENCE, 2020, 14
  • [27] Enhanced regenerative axon growth of multiple fibre populations in traumatic spinal cord injury following scar-suppressing treatment
    Schiwy, Nora
    Brazda, Nicole
    Mueller, Hans Werner
    EUROPEAN JOURNAL OF NEUROSCIENCE, 2009, 30 (08) : 1544 - 1553
  • [28] Differential effect of aging on axon sprouting and regenerative growth in spinal cord injury
    Jaerve, Anne
    Schiwy, Nora
    Schmitz, Christine
    Mueller, Hans W.
    EXPERIMENTAL NEUROLOGY, 2011, 231 (02) : 284 - 294
  • [29] The regenerative potential of the axolotl spinal cord: A blunt spinal cord injury model
    Thygesen, Mathias Moeller
    Lauridsen, Henrik
    Pedersen, Michael
    Rasmussen, Mikkel Mylius
    FASEB JOURNAL, 2016, 30
  • [30] EFFECT OF GLIAL-EPENDYMAL SCAR AND TEFLON ARREST ON REGENERATIVE CAPACITY OF GOLDFISH SPINAL CORD
    BERNSTEIN, JJ
    BERNSTEIN, ME
    EXPERIMENTAL NEUROLOGY, 1967, 19 (01) : 25 - +