Recent Advances in Polyanhydride Based Biomaterials

被引：67

作者：

Basu, Arijit ^{[1
,2
]}

Domb, Abraham J. ^{[1
]}

机构：

[1] Hebrew Univ Jerusalem, Sch Pharm, Fac Med, Hadassah Kerem Med Ctr Campus, IL-91120 Jerusalem, Israel

[2] MIT, Koch Inst Integrat Canc Res, Room 617,500 Main St, Cambridge, MA 02131 USA

来源：

ADVANCED MATERIALS | 2018年 / 30卷 / 41期

关键词：

alternating polyanhydride; bioelectronics; melt condensation; poly(ester-anhydride); polyanhydride; vaccine delivery; ACID) BIODEGRADABLE CARRIER; CROSS-LINKED POLYANHYDRIDES; IN-VIVO; RICINOLEIC ACID; DRUG-DELIVERY; RELEASE APPLICATIONS; ADIPIC ANHYDRIDE; DIBASIC ACIDS; BRAIN-TUMORS; SEBACIC ACID;

D O I：

10.1002/adma.201706815

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This review focusses on recent developments of polyanhydrides, a class of degradable synthetic biopolymers. Polyanhydrides have been used as carriers for controlled delivery of drugs. A polyanhydride copolymer of carboxyphenoxy propane and sebacic acid has been used in Gliadel brain tumor implants for the controlled delivery of carmustine or bis-chloroethylnitrosourea. They are easy and inexpensive to synthesize (especially scale up). However, polyanhydrides possess a short shelf-life. Hydrolytic cleavage and anhydride interchanges lower their molecular weights during storage. One of the highlights in recent developments of polyanhydride chemistry is the discovery of alternating copolymers having extended shelf-life. Other highlights include their applications in biomedical electronics, vaccine delivery, and nano/micro particulate delivery systems. This review examines approaches for polyanhydride synthesis followed by their recent developments in biomedical applications.

引用

页数：10

共 95 条

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