A systematic review of photodynamic therapy as an antiviral treatment: Potential guidance for dealing with SARS-CoV-2

被引：37

作者：

Conrado, Pollyanna C. V. ^{[1
]}

Sakita, Karina M. ^{[1
]}

Arita, Glaucia S. ^{[1
]}

Galinari, Camila B. ^{[1
]}

Goncalves, Renato S. ^{[2
]}

Lopes, Luciana D. G. ^{[1
]}

Lonardoni, Maria V. C. ^{[1
]}

Teixeira, Jorge J. V. ^{[1
]}

Bonfim-Mendonca, Patricia S. ^{[1
]}

Kioshima, Erika S. ^{[1
]}

机构：

[1] Univ Estadual Maringa, Dept Anal Clin & Biomed, Maringa, Parana, Brazil

[2] Univ Estadual Maringa, Dept Chem, Maringa, Parana, Brazil

来源：

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY | 2021年 / 34卷

关键词：

Photodynamic therapy; Photosensitizers; Photoinactivation; Viruses; SARS-CoV-2; HUMAN-IMMUNODEFICIENCY-VIRUS; INACTIVATION; PHOTOINACTIVATION; PLASMA; PHTHALOCYANINES; AMOTOSALEN; PATHOGENS; CURCUMIN;

D O I：

10.1016/j.pdpdt.2021.102221

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: SARS-CoV-2, which causes the coronavirus disease (COVID-19), presents high rates of morbidity and mortality around the world. The search to eliminate SARS-CoV-2 is ongoing and urgent. This systematic review seeks to assess whether photodynamic therapy (PDT) could be effective in SARS-CoV-2 inactivation. Methods: The focus question was: Can photodynamic therapy be used as potential guidance for dealing with SARS-CoV-2?". A literature search, according to PRISMA statements, was conducted in the electronic databases PubMed, EMBASE, SCOPUS, Web of Science, LILACS, and Google Scholar. Studies published from January 2004 to June 2020 were analyzed. In vitro and in vivo studies were included that evaluated the effect of PDT mediated by several photosensitizers on RNA and DNA enveloped and non-enveloped viruses. Results: From 27 selected manuscripts, 26 publications used in vitro studies, 24 were exclusively in vitro, and two had in vitro/in vivo parts. Only one analyzed publication was exclusively in vivo. Meta-analysis studies were unfeasible due to heterogeneity of the data. The risk of bias was analyzed in all studies. Conclusion: The in vitro and in vivo studies selected in this systematic review indicated that PDT is capable of photoinactivating enveloped and non-enveloped DNA and RNA viruses, suggesting that PDT can potentially photoinactivate SARS-CoV-2.

引用

页数：22

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