ALG/Ca Beads as an Encapsulation Agent of Croton Zehntneri Pax et Hoffm Essential Oil

被引:24
|
作者
de Paula, Haroldo C. B. [1 ]
de Oliveira, Erick F. [1 ]
Abreu, Flavia O. M. S. [1 ]
de Paula, Regina C. M. [2 ]
de Morais, Selene M.
Forte, Maria M. C. [3 ]
机构
[1] Univ Fed Ceara, Dept Quim Analit & Fisicoquim, BR-60451970 Fortaleza, Ceara, Brazil
[2] Univ Fed Ceara, Dept Quim Organ & Inorgan, BR-60451970 Fortaleza, Ceara, Brazil
[3] Univ Fed Rio Grande do Sul, Lab Mat Polimericos, Porto Alegre, RS, Brazil
来源
POLIMEROS-CIENCIA E TECNOLOGIA | 2010年 / 20卷 / 02期
关键词
Alginate; spheres; cashew gum; encapsulation; Stegomyia aegypti; IN-VITRO RELEASE; SODIUM ALGINATE; DRUG-RELEASE; MICROSPHERES; MICROPARTICLES; KINETICS;
D O I
10.1590/S0104-14282010005000019
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
Alginate beads (ALG) crosslinked with calcium and coated with cashew gum (GC) were prepared and loaded with an essential oil from Croton zehntneri Pax et Hoffin (Cz). The beads were characterized by FTIR, thermal properties, with respect to their size, shape, larvicide loading, swelling, and in vitro and in vivo release kinetics. Results showed that beads with ALG:Cz =1:1 relative ratio showed higher loading and encapsulation efficiency, although presenting a faster release kinetics. On the other hand, ALG beads coated with GC showed Q values from 10 to 12, representing a significant increase in the hydrophilic character of the matrix. Infrared spectroscopy and thermal analysis confirmed the presence of essential oil encapsulated in beads. Morphologic investigation by SEM revealed a highly spherical and porous surface. The in vitro profile showed that the Cz oil encapsulated had a prolonged release in ALG-GC beads, probably due to the crosslinking. In vivo tests showed that the mortality degree was related to the mass of the beads, where beads having oil content from 1.81 to 4.25 mg caused larvae mortalities from 72 to 100% after 24 h. The control release system was found to be effective up to 70 days. These results showed that ALG-GC beads loaded with Cz are promising candidate for the control of Stegomyia aegypti larvae.
引用
收藏
页码:112 / 120
页数:9
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