Inefficacy of exchange-transfusion in a methotrexate intoxication

被引：0

作者：

Benezet, S

Chatelut, E

Bagheri, H

RigalHuguet, F

Nguyen, L

Pourrat, J

Robert, A

Montastruc, JL

Canal, P

机构：

[1] CTR CLAUDIUS REGAUD,UNITE PHARMACOCINET CLIN,F-31052 TOULOUSE,FRANCE

[2] FAC MED TOULOUSE,SERV PHARMACOL CLIN,CTR MIDI PYRENEES PHARMACOVIGILANCE PHARMACOEPIDE,F-31073 TOULOUSE,FRANCE

[3] CHU PURPAN,F-31059 TOULOUSE,FRANCE

来源：

BULLETIN DU CANCER | 1997年 / 84卷 / 08期

关键词：

exchange-transfusion; methotrexate; impaired renal function;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We report on a case of methotrexate (MTX) intoxication occurring in a 19-year-old man treated for a leukemia. Exchange-transfusion (ET) was performed in attempt to remove the MTX from the body. This exchange-transfusion was unable to decrease the MTX plasma concentration. This inefficacy of ET in MTX intoxication is in contradiction with previously reported recommendations. However, this result is easily explained by MTX pharmacokinetics parameters.

引用

页码：788 / 790

页数：3

共 8 条

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