Direct cadherin-activated cell signaling: a view from the plasma membrane

被引：250

作者：

Yap, AS ^{[1
]}

Kovacs, EM

机构：

[1] Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia

[2] Univ Queensland, Sch Biomed Sci, Brisbane, Qld 4072, Australia

来源：

JOURNAL OF CELL BIOLOGY | 2003年 / 160卷 / 01期

基金：

英国惠康基金;

关键词：

cadherin; Rac; actin cytoskeleton; Rho GTPase; PI3; kinase;

D O I：

10.1083/jcb.200208156

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Classical cadherin adhesion molecules are key determinants of cell recognition and tissue morphogenesis, with diverse effects on cell behavior. Recent developments indicate that classical cadherins are adhesion-activated signaling receptors. In particular, early-immediate Rac signaling is emerging as a mechanism to coordinate cadherin-actin integration at the plasma membrane.

引用

页码：11 / 16

页数：6

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