1,6-Conjugate-Addition-Induced [2+1] Annulation of para-Quinone Methides and Pyrazolones: Synthesis of Bis-Spiro Compounds with Contiguous Quaternary Spiro-Centers

被引：33

作者：

Kale, Someshwar B. ^{[1
,3
]}

Jori, Popat K. ^{[1
]}

Thatikonda, Thanusha ^{[1
]}

Gonnade, Rajesh G. ^{[2
,3
]}

Das, Utpal ^{[1
,3
]}

机构：

[1] Natl Chem Lab, Div Organ Chem, CSIR, Pune 411008, Maharashtra, India

[2] Natl Chem Lab, Ctr Mat Characterizat, CSIR, Pune 411008, Maharashtra, India

[3] Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, India

来源：

ORGANIC LETTERS | 2019年 / 21卷 / 19期

关键词：

CATALYTIC ENANTIOSELECTIVE CONSTRUCTION; 1,6-CONJUGATE ADDITION; DNA ALKYLATION; SULFONIUM SALTS; DEAROMATIZATION; SPIROCYCLOPROPANATION; TEMPERATURE;

D O I：

10.1021/acs.orglett.9b02641

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A diastereoselective formal 1,6-conjugate-addition-mediated [2 + 1] annulation reaction using p-quinone methides and pyrazolones has been described. The corresponding bis-spiro[cyclohexadienone-cyclopropane-pyrazolone] compounds were obtained in very good yield under mild reaction conditions.

引用

页码：7736 / 7740

页数：5