Bone biomarker for the clinical assessment of osteoporosis: recent developments and future perspectives

被引：357

作者：

Kuo, Tsung-Rong ^{[1
,2
]}

Chen, Chih-Hwa ^{[3
,4
]}

机构：

[1] Taipei Med Univ, Grad Inst Nanomed & Med Engn, Coll Biomed Engn, Taipei 11031, Taiwan

[2] Taipei Med Univ, Int PhD Program Biomed Engn, Coll Biomed Engn, Taipei 11031, Taiwan

[3] Taipei Med Univ Hosp, Dept Orthoped & Traumatol, Bone & Joint Res Ctr, Taipei 11031, Taiwan

[4] Taipei Med Univ, Sch Med, Coll Med, Taipei 11031, Taiwan

来源：

BIOMARKER RESEARCH | 2017年 / 5卷

关键词：

Bone biomarker; Bone formation; Bone resorption; Regulators; Bone turnover; Osteoporosis; ALKALINE-PHOSPHATASE ISOENZYMES; OSTEOCLASTOGENESIS-INHIBITORY FACTOR; WHEAT-GERM LECTIN; TERMINAL PROPEPTIDE; POSTMENOPAUSAL WOMEN; TURNOVER MARKERS; MINERAL DENSITY; I PROCOLLAGEN; SERUM MARKERS; DEOXYPYRIDINOLINE;

D O I：

10.1186/s40364-017-0097-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Bone biomarkers included formation, resorption and regulator are released during the bone remodeling processes. These bone biomarkers have attracted much attention in the clinical assessment of osteoporosis treatment in the past decade. Combination with the measurement of bone mineral density, the clinical applications of bone biomarkers have provided comprehensive information for diagnosis of osteoporosis. However, the analytical approaches of the bone biomarkers are still the challenge for further clinical trials. In this mini-review, we have introduced the functions of bone biomarkers and then recently developed techniques for bone biomarker measurements have been systematically integrated to discuss the possibility for osteoporosis assessment in the early stage.

引用

页数：9

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