Inhibiting MEK in MAPK pathway-activated myeloma

被引：79

作者：

Heuck, C. J. ^{[1
]}

Jethava, Y. ^{[1
]}

Khan, R. ^{[1
]}

van Rhee, F. ^{[1
]}

Zangari, M. ^{[1
]}

Chavan, S. ^{[1
]}

Robbins, K. ^{[1
]}

Miller, S. E. ^{[1
]}

Matin, A. ^{[1
]}

Mohan, M. ^{[1
]}

Ali, S. M. ^{[2
]}

Stephens, P. J. ^{[2
]}

Ross, J. S. ^{[2
,3
]}

Miller, V. A. ^{[2
]}

Davies, F. ^{[1
]}

Barlogie, B. ^{[1
]}

Morgan, G. ^{[1
]}

机构：

[1] Univ Arkansas Med Sci, Myeloma Inst, Little Rock, AR 72205 USA

[2] Fdn Med Inc, Cambridge, MA USA

[3] Albany Med Coll, Dept Pathol, Albany, NY 12208 USA

来源：

LEUKEMIA | 2016年 / 30卷 / 04期

关键词：

MULTIPLE-MYELOMA; TOTAL THERAPY; WILD-TYPE; HETEROGENEITY; BORTEZOMIB; RISK; RAF;

D O I：

10.1038/leu.2015.208

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

引用

页码：976 / 980

页数：6

共 15 条

[1] Targeting the BRAF V600E Mutation in Multiple Myeloma [J].

Andrulis, Mindaugas ;

Lehners, Nicola ;

Capper, David ;

Penzel, Roland ;

Heining, Christoph ;

Huellein, Jennifer ;

Zenz, Thorsten ;

von Deimling, Andreas ;

Schirmacher, Peter ;

Ho, Anthony D. ;

Goldschmidt, Hartmut ;

Neben, Kai ;

Raab, Marc S. .

CANCER DISCOVERY, 2013, 3 (08) :862-869

[2] A mechanistic rationale for MEK inhibitor therapy in myeloma based on blockade of MAF oncogene expression [J].

Annunziata, Christina M. ;

Hernandez, Lidia ;

Davis, R. Eric ;

Zingone, Adriana ;

Lamy, Laurence ;

Lam, Lloyd T. ;

Hurt, Elaine M. ;

Shaffer, Arthur L. ;

Kuehl, W. Michael ;

Staudt, Louis M. .

BLOOD, 2011, 117 (08) :2396-2404

[3] Early results of Total Therapy II in multiple myeloma: Implications of cytogenetics and FISH [J].

Barlogie, B ;

Shaughnessy, JD .

INTERNATIONAL JOURNAL OF HEMATOLOGY, 2002, 76 (Suppl 1) :337-339

[4] Total therapy with tandem transplants for newly diagnosed multiple myeloma [J].

Barlogie, B ;

Jagannath, S ;

Desikan, KR ;

Mattox, S ;

Vesole, D ;

Siegel, D ;

Tricot, G ;

Munshi, N ;

Fassas, A ;

Singhal, S ;

Mehta, J ;

Anaissie, E ;

Dhodapkar, D ;

Naucke, S ;

Cromer, J ;

Sawyer, J ;

Epstein, J ;

Spoon, D ;

Ayers, D ;

Cheson, B ;

Crowley, J .

BLOOD, 1999, 93 (01) :55-65

[5] Incorporating bortezomib into upfront treatment for multiple myeloma: early results of total therapy 3 [J].

Barlogie, Bart ;

Anaissie, Elias ;

van Rhee, Frits ;

Haessler, Jeffrey ;

Hollmig, Klaus ;

Pineda-Roman, Mauricio ;

Cottler-Fox, Michele ;

Mohiuddin, Abid ;

Alsayed, Yazan ;

Tricot, Guido ;

Bolejack, Vanessa ;

Zangari, Maurizio ;

Epstein, Joshua ;

Petty, Nathan ;

Steward, Douglas ;

Jenkins, Bonnie ;

Gurley, Jennifer ;

Sullivan, Ellen ;

Crowley, John ;

Shaughnessy, John D. Jr .

BRITISH JOURNAL OF HAEMATOLOGY, 2007, 138 (02) :176-185

[6] Heterogeneity of genomic evolution and mutational profiles in multiple myeloma [J].

Bolli, Niccolo ;

Avet-Loiseau, Herve ;

Wedge, David C. ;

Van Loo, Peter ;

Alexandrov, Ludmil B. ;

Martincorena, Inigo ;

Dawson, Kevin J. ;

Iorio, Francesco ;

Nik-Zainal, Serena ;

Bignell, Graham R. ;

Hinton, Jonathan W. ;

Li, Yilong ;

Tubio, Jose M. C. ;

McLaren, Stuart ;

Meara, Sarah O' ;

Butler, Adam P. ;

Teague, Jon W. ;

Mudie, Laura ;

Anderson, Elizabeth ;

Rashid, Naim ;

Tai, Yu-Tzu ;

Shammas, Masood A. ;

Sperling, Adam S. ;

Fulciniti, Mariateresa ;

Richardson, Paul G. ;

Parmigiani, Giovanni ;

Magrangeas, Florence ;

Minvielle, Stephane ;

Moreau, Philippe ;

Attal, Michel ;

Facon, Thierry ;

Futreal, P. Andrew ;

Anderson, Kenneth C. ;

Campbell, Peter J. ;

Munshi, Nikhil C. .

NATURE COMMUNICATIONS, 2014, 5

[7] Initial genome sequencing and analysis of multiple myeloma [J].

Chapman, Michael A. ;

Lawrence, Michael S. ;

Keats, Jonathan J. ;

Cibulskis, Kristian ;

Sougnez, Carrie ;

Schinzel, Anna C. ;

Harview, Christina L. ;

Brunet, Jean-Philippe ;

Ahmann, Gregory J. ;

Adli, Mazhar ;

Anderson, Kenneth C. ;

Ardlie, Kristin G. ;

Auclair, Daniel ;

Baker, Angela ;

Bergsagel, P. Leif ;

Bernstein, Bradley E. ;

Drier, Yotam ;

Fonseca, Rafael ;

Gabriel, Stacey B. ;

Hofmeister, Craig C. ;

Jagannath, Sundar ;

Jakubowiak, Andrzej J. ;

Krishnan, Amrita ;

Levy, Joan ;

Liefeld, Ted ;

Lonial, Sagar ;

Mahan, Scott ;

Mfuko, Bunmi ;

Monti, Stefano ;

Perkins, Louise M. ;

Onofrio, Robb ;

Pugh, Trevor J. ;

Rajkumar, S. Vincent ;

Ramos, Alex H. ;

Siegel, David S. ;

Sivachenko, Andrey ;

Stewart, A. Keith ;

Trudel, Suzanne ;

Vij, Ravi ;

Voet, Douglas ;

Winckler, Wendy ;

Zimmerman, Todd ;

Carpten, John ;

Trent, Jeff ;

Hahn, William C. ;

Garraway, Levi A. ;

Meyerson, Matthew ;

Lander, Eric S. ;

Getz, Gad ;

Golub, Todd R. .

NATURE, 2011, 471 (7339) :467-472

[8] International uniform response criteria for multiple myeloma [J].

Durie, B. G. M. ;

Harousseau, J-L ;

Miguel, J. S. ;

Blade, J. ;

Barlogie, B. ;

Anderson, K. ;

Gertz, M. ;

Dimopoulos, M. ;

Westin, J. ;

Sonneveld, P. ;

Ludwig, H. ;

Gahrton, G. ;

Beksac, M. ;

Crowley, J. ;

Belch, A. ;

Boccadaro, M. ;

Turesson, I. ;

Joshua, D. ;

Vesole, D. ;

Kyle, R. ;

Alexanian, R. ;

Tricot, G. ;

Attal, M. ;

Merlini, G. ;

Powles, R. ;

Richardson, P. ;

Shimizu, K. ;

Tosi, P. ;

Morgan, G. ;

Rajkumar, S. V. .

LEUKEMIA, 2006, 20 (09) :1467-1473

[9] Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization [J].

Garnett, MJ ;

Rana, S ;

Paterson, H ;

Barford, D ;

Marais, R .

MOLECULAR CELL, 2005, 20 (06) :963-969

[10] GSK1120212 (JTP-74057) Is an Inhibitor of MEK Activity and Activation with Favorable Pharmacokinetic Properties for Sustained In Vivo Pathway Inhibition [J].

Gilmartin, Aidan G. ;

Bleam, Maureen R. ;

Groy, Arthur ;

Moss, Katherine G. ;

Minthorn, Elisabeth A. ;

Kulkarni, Swarupa G. ;

Rominger, Cynthia M. ;

Erskine, Symon ;

Fisher, Kelly E. ;

Yang, Jingsong ;

Zappacosta, Francesca ;

Annan, Roland ;

Sutton, David ;

Laquerre, Sylvie G. .

CLINICAL CANCER RESEARCH, 2011, 17 (05) :989-1000

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