Chromosomal Instability in Tumor Initiation and Development

被引：76

作者：

Bach, Duc-Hiep ^{[1
]}

Zhang, Wei ^{[2
]}

Sood, Anil K. ^{[1
,3
,4
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Gynecol Oncol & Reprod Med, Houston, TX 77030 USA

[2] Wake Forest Baptist Comprehens Canc Ctr, Ctr Canc Genom & Precis Oncol, Winston Salem, NC USA

[3] Univ Texas MD Anderson Canc Ctr, Dept Canc Biol, Houston, TX 77030 USA

[4] Univ Texas MD Anderson Canc Ctr, Ctr RNA Interference & Noncoding RNA, Houston, TX 77030 USA

来源：

CANCER RESEARCH | 2019年 / 79卷 / 16期

关键词：

SPINDLE ASSEMBLY CHECKPOINT; PRIMARY BREAST CANCERS; TELOMERE DYSFUNCTION; COPY NUMBER; CENTROSOME AMPLIFICATION; GENOME INSTABILITY; DRUG-RESISTANCE; PROSTATE-CANCER; EARLY EVENTS; EVOLUTION;

D O I：

10.1158/0008-5472.CAN-18-3235

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Chromosomal instability (CIN) is one of the major forms of genomic instability in various human cancers and is recognized as a common hallmark of tumorigenesis and heterogeneity. However, some malignant tumors show a paucity of chromosomal alterations, suggesting that tumor progression and evolution can occur in the absence of CIN. It is unclear whether CIN is stable between precursor lesions, primary tumor, and metastases or if it evolves during these steps. In this review, we describe the influence of CIN on the various steps in tumor initiation and development. Given the recognized significant effects of CIN in cancer, CIN-targeted therapeutics could have a major impact on improving clinical outcomes.

引用

页码：3995 / 4002

页数：8

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