Pharmacokinetic Interactions between Cardiovascular Medicines and Plant Products

被引：10

作者：

Costache, Irina-Iuliana ^{[1
,2
]}

Miron, Anca ^{[3
]}

Hancianu, Monica ^{[3
]}

Aursulesei, Viviana ^{[1
,2
]}

Costache, Alexandru Dan ^{[1
]}

Aprotosoaie, Ana Clara ^{[3
]}

机构：

[1] Grigore T Popa Univ Med & Pharm Iasi, Fac Med, Iasi 700115, Romania

[2] Sf Spiridon Univ Hosp, Iasi 700111, Romania

[3] Grigore T Popa Univ Med & Pharm Iasi, Fac Pharm, Iasi 700115, Romania

来源：

CARDIOVASCULAR THERAPEUTICS | 2019年 / 2019卷

关键词：

ST-JOHNS-WORT; INCREASES SERUM CONCENTRATIONS; JUICE-FELODIPINE INTERACTION; HERB-DRUG INTERACTIONS; GRAPEFRUIT JUICE; GINKGO-BILOBA; GREEN TEA; PLASMA-CONCENTRATIONS; DIETARY-SUPPLEMENTS; P-GLYCOPROTEIN;

D O I：

10.1155/2019/9402781

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The growing use of plant products among patients with cardiovascular pharmacotherapy raises the concerns about their potential interactions with conventional cardiovascular medicines. Plant products can influence pharmacokinetics or/and pharmacological activity of coadministered drugs and some of these interactions may lead to unexpected clinical outcomes. Numerous studies and case reports showed various pharmacokinetic interactions that are characterized by a high degree of unpredictability. This review highlights the pharmacokinetic clinically relevant interactions between major conventional cardiovascular medicines and plant products with an emphasis on their putative mechanisms, drawbacks of herbal products use, and the perspectives for further well-designed studies.

引用

页数：19

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