Nomenclature and definition of metabolic-associated fatty liver disease: a consensus from the Middle East and north Africa

被引：96

作者：

Shiha, Gamal ^{[1
,2
]}

Alswat, Khalid ^{[3
]}

Al Khatry, Maryam ^{[4
]}

Sharara, Ala, I ^{[5
]}

Ormeci, Necati ^{[6
]}

Waked, Imam ^{[7
]}

Benazzouz, Mustapha ^{[8
]}

Al-Ali, Fuad ^{[9
]}

Hamed, Abd Elkhalek ^{[10
]}

Hamoudi, Waseem ^{[11
]}

Attia, Dina ^{[12
]}

Derbala, Moutaz ^{[13
]}

Sharaf-Eldin, Mohamed ^{[14
]}

Al-Busafi, Said A. ^{[15
]}

Zaky, Samy ^{[16
]}

Bamakhrama, Khaled ^{[17
]}

Ibrahim, Nazir ^{[18
]}

Ajlouni, Yousef ^{[19
]}

Sabbah, Meriam ^{[20
]}

Salama, Mohsen ^{[7
]}

Anushiravani, Amir ^{[21
]}

Afredj, Nawel ^{[22
]}

Barakat, Salma ^{[23
]}

Hashim, Almoutaz ^{[24
]}

Fouad, Yasser ^{[25
]}

Soliman, Reham ^{[1
,26
]}

机构：

[1] Egyptian Liver Res Inst & Hosp, Mansoura 35111, Egypt

[2] Mansoura Univ, Fac Med, Internal Med Dept, Hepatol & Gastroenterol Unit, Mansoura, Egypt

[3] King Saud Univ, Coll Med, Liver Dis Res Ctr, Riyadh, Saudi Arabia

[4] Obaidulla Hosp, Dept Gastroenterol, Ras Al Khaymah, U Arab Emirates

[5] Amer Univ, Dept Internal Med, Div Gastroenterol, Beirut Med Ctr, Beirut, Lebanon

[6] Ankara Univ, Dept Gastroenterol, Sch Med, Ankara, Turkey

[7] Menoufia Univ, Natl Liver Inst, Dept Hepatol & Gastroenterol, Shibin Al Kawm, Egypt

[8] Ctr Hosp Univ Ibn Sina, Serv Med C, Rabat, Morocco

[9] Kuwait Univ, Royal Hayat Hosp, Fac Med, Dept Gastroenterol, Kuwait, Kuwait

[10] Egyptian Mil Med Acad, Dept Internal Med Hepatol & Diabet, Cairo, Egypt

[11] Al Bashir Hosp, Internal Med Dept, Amman, Jordan

[12] Beni Suef Univ, Fac Med, Dept Hepatol Gastroenterol & Endem Med, Bani Suwayf, Egypt

[13] Hamad Med Corp, Gastroenterol & Hepatol Dept, Doha, Qatar

[14] Tanta Univ, Fac Med, Dept Gastroenterol & Hepatol, Tanta, Egypt

[15] Sultan Qaboos Univ, Coll Med & Hlth Sci, Dept Med, Muscat, Oman

[16] Al Azhar Univ, Dept Hepatogastroenterol & Infect Dis, Cairo, Egypt

[17] Rashid Hosp, Dept Gastroenterol, Dubai, U Arab Emirates

[18] Kalamoon Univ, Dept Gastroenterol & Hepatol, Damascus, Syria

[19] King Hussein Med City, Royal Med Serv, Dept Internal Med, Amman, Jordan

[20] Habib Thameur Hosp, Dept Gastroenterol, Tunis, Tunisia

[21] Univ Tehran Med Sci, Shariati Hosp, Digest Dis Res Inst, Tehran, Iran

[22] Mustapha Hosp, Hepatol Unit, Dept Med, Algiers, Algeria

[23] Ibn Sina Hosp, Natl Ctr Gastrointestinal & Liver Dis, Minist Hlth, Khartoum, Sudan

[24] Jeddah Univ, Dept Internal Med, Jeddah, Saudi Arabia

[25] Minya Univ Hosp, Fac Med, Dept Gastroenterol Hepatol & Endem Med, Al Minya, Egypt

[26] Port Said Univ, Fac Med, Trop Med Dept, Port Said, Egypt

来源：

LANCET GASTROENTEROLOGY & HEPATOLOGY | 2021年 / 6卷 / 01期

关键词：

OBESITY; NAFLD;

D O I：

10.1016/S2468-1253(20)30213-2

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

With the increasing prevalence of obesity and type 2 diabetes, fatty liver disease associated with metabolic dysfunction is a global health problem, especially because it is one of the earliest consequences of obesity and it precedes diabetes development. Fatty liver disease associated with metabolic dysfunction is of particular concern in the Middle East and north Africa, where its prevalence is greater than that in the rest of the world. Despite the magnitude of the problem, no regional guidelines have been developed to address this disease. This Review describes suggestions of redefining fatty liver disease associated with metabolic dysfunction, including its terminology and criteria for diagnosis. Experts have raised serious concerns on the current nomenclature, which labels the disease as non-alcoholic fatty liver disease (NAFLD), and its diagnostic criteria. The panel reached a consensus that the disease should be renamed as metabolic-associated fatty liver disease (MAFLD) and that the disease should be diagnosed by positive criteria. The aim is now to work with authorities across the region to implement these proposed changes and reflect them in health-care policy and to improve health care for patients in this region.

引用

页码：57 / 64

页数：8

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