A convenient synthesis of (+)-albicanol based on enzymatic function: total syntheses of (+)-albicanyl acetate, (-)-albicanyl 3,4-dihydroxycinnamate, (-)-drimenol, (-)-drimenin and (-)-ambrox

被引：53

作者：

Akita, H ^{[1
]}

Nozawa, M ^{[1
]}

Mitsuda, A ^{[1
]}

Ohsawa, H ^{[1
]}

机构：

[1] Toho Univ, Sch Pharmaceut Sci, Funabashi, Chiba 2748510, Japan

来源：

TETRAHEDRON-ASYMMETRY | 2000年 / 11卷 / 06期

关键词：

D O I：

10.1016/S0957-4166(00)00076-8

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

By using lipase 'PL-266' from Alcaligenes sp. enantioselective acetylation of (+/-)-albicanol 4 with isopropenyl acetate gave the enantiomerically pure (+)-albicanyl acetate 3 and (+)-albicanol 4. Deprotection of (+)-3 afforded the natural (+)-albicanol 4 which was converted to the natural products (-)-albicanyl 3,4-dihydroxycinnamate 7, (-)-drimenol 8, (-)-drimenin 9 and (-)-ambrox 10. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1375 / 1388

页数：14

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