Cisd2 mediates mitochondrial integrity and life span in mammals

被引：62

作者：

Chen, Yi-Fan ^{[1
,2
,4
]}

Kao, Cheng-Heng ^{[3
]}

Kirby, Ralph ^{[1
,2
]}

Tsai, Ting-Fen ^{[1
,2
,4
]}

机构：

[1] Natl Yang Ming Univ, Dept Life Sci, Taipei 112, Taiwan

[2] Natl Yang Ming Univ, Inst Genome Sci, Taipei 112, Taiwan

[3] Chang Gung Univ, Ctr Gen Educ, Tao Yuan, Taiwan

[4] Natl Hlth Res Inst, Div Mol & Genom Med, Zhunan, Miaoli County, Taiwan

来源：

AUTOPHAGY | 2009年 / 5卷 / 07期

关键词：

Cisd2; knockout mice; mitochondria; autophagy; premature aging;

D O I：

10.4161/auto.5.7.9351

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

CISD2, the causative gene for Wolfram syndrome 2 (WFS2), is a previously uncharacterized novel gene. Using a mouse genetic approach, this work demonstrated for the first time that Cisd2 is involved in mammalian life span control. Cisd2 deficiency in mice leads to mitochondrial breakdown and dysfunction; this is accompanied by cell death with autophagic features and these events precede the two earliest manifestations of nerve and muscle degeneration. Together, they lead to a panel of phenotypic features suggestive of premature aging. This work effectively links Cisd2 gene function, mitochondrial integrity and aging in mammals.

引用

页码：1043 / 1045

页数：3