Radical-scavenging activity of nitroxyl radical as an electron donor

被引：0

作者：

Manda, S. ^{[1
]}

Kawaguchi, K. ^{[1
,2
,3
]}

Ohkubo, K. ^{[2
]}

Kawashima, T. ^{[1
,2
,3
]}

Kanazawa, H. ^{[3
,4
]}

Takeshita, K.

Anzai, K. ^{[1
]}

Ozawa, T. ^{[1
,5
]}

Fukuzumi, S. ^{[2
]}

Ikota, N. ^{[6
]}

Nakanishi, I. ^{[1
,2
]}

机构：

[1] Natl Inst Radiol Sci, Res Ctr Charged Particle Therapy, Heavy Ion Radiobiol Res Grp, Inage Ku, Chiba 2638555, Japan

[2] Osaka Univ, Grad Sch Engn, Dept Mat & Life Sci, SORST, Osaka, Japan

[3] Kyoritsu Univ Pharm, Dept Phys Pharmaceut Chem, Minato Ku, Tokyo 1088512, Japan

[4] Sojo Univ, Fac Pharmaceut Sci, Ikeda, Kumamoto 8600082, Japan

[5] Tohoku Univ, New Ind Creat Hatchery Ctr, Sendai, Miyagi 9808579, Japan

[6] Natl Inst Radiol Sci, Med Treatment High Dose Exposure Res Grp, Res Ctr Radiat Emergency Med, Inage Ku, Chiba 2638555, Japan

来源：

PROCEEDINGS OF THE XIII CONGRESS OF THE SOCIETY FOR FREE RADICAL RESEARCH INTERNATIONAL | 2006年

关键词：

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cumylperoxyl radical (PhCMe2OO.), generated under irradiation of a propionitrile solution of cumene, di-tert-butyl peroxide, and O-2 at 193 K, was efficiently scavenged by 3-carbamoyl-2,2,5,5-tetramethylpyrrolidine- N-oxyl (CP), a frequently used spin probe for in vivo electron spin resonance (ESR) measurements. The scavenging rate is found to be accelerated in the presence of SC(OSO2CF3)(3), indicating that CP scavenges PhCMe2OO. via an electron transfer from CP to PhCMe2OO. rather than via a radical-coupling reaction. The coordination Of Sc3+ to PhCMe2OO- thus produced decreases the free energy change of the electron transfer, resulting in the acceleration of the scavenging reaction.

引用

页码：237 / +

页数：2

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