The pretreatment lymphocyte to monocyte ratio predicts clinical outcome for patients with hepatocellular carcinoma: A meta-analysis

被引：39
作者：
Song, Wei [1 ]
Tian, Chuan [2 ]
Wang, Kai [1 ]
Zhang, Run-jin [1 ]
Zou, Shu-bing [1 ]
机构：
[1] Nanchang Univ, Affiliated Hosp 2, Dept Hepatobiliary Surg, 1 Minde Rd, Nanchang, Jiangxi, Peoples R China
[2] Guizhou Prov Peoples Hosp, Dept Nucl Med, Guiyang, Peoples R China
来源：
SCIENTIFIC REPORTS | 2017年 / 7卷
关键词：
REGULATORY T-CELLS; INFLAMMATORY CELL; TUMOR PROGRESSION; POOR-PROGNOSIS; SURVIVAL; CANCER; INFILTRATION; MACROPHAGES; STATISTICS;
D O I：
10.1038/srep46601
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The lymphocyte-to-monocyte ratio (LMR) has been reported to predict clinical outcomes in multiple malignancies. The aim of this study was to assess the prognostic role of pretreatment LMR in hepatocellular carcinoma (HCC). A total of seven studies comprising 2,738 patients were included in the meta-analysis. Pooled results showed that elevated LMR was significantly associated with increased overall survival (OS) (HR: 0.31, 95% CI: 0.20-0.47, p < 0.001), disease-free survival (DFS)/recurrence-free survival (RFS) (HR: 0.57, 95% CI: 0.49-0.67, p < 0.001). The favorable prognostic impact of high LMR on OS was observed in all subgroup with different sample size, type of publication, NOS score, and the cut-off value of LMR. In addition, low LMR was significantly correlated with TNM stage and BCLC stage. We therefore conclude that elevated pretreatment LMR could be a favorable prognostic factor for clinical outcomes in patients with HCC.
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页数：7
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