An enzymatic route to 5-deoxy-5-[18F]fluoro-D-ribose, a [18F]-fluorinated sugar for PET imaging

被引：38
作者：
Onega, Mayca [1 ,2 ,3 ]
Domarkas, Juozas [3 ]
Deng, Hai [4 ]
Schweiger, Lutz F. [3 ]
Smith, Timothy A. D. [3 ]
Welch, Andrew E. [3 ]
Plisson, Christophe [5 ]
Gee, Antony D. [5 ]
O'Hagan, David [1 ,2 ]
机构：
[1] Univ St Andrews, Sch Chem, St Andrews KY16 9ST, Fife, Scotland
[2] Univ St Andrews, Ctr Biomol Sci, St Andrews KY16 9ST, Fife, Scotland
[3] Univ Aberdeen, John Mallard Scottish PET Ctr, Sch Med Sci, Aberdeen AB25 2ZD, Scotland
[4] Univ Aberdeen, UK Marine Biodiscovery Ctr, Dept Chem, Aberdeen AB24 3UE, Scotland
[5] Univ London Imperial Coll Sci Technol & Med, GSK Clin Imaging Ctr, Hammersmith Hosp, London W12 0NN, England
来源：
CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 01期
基金：
英国生物技术与生命科学研究理事会; 英国医学研究理事会;
关键词：
NUCLEOSIDE HYDROLASE; L-TRYPTOPHAN; T; VIVAX; FLUORINASE; COMPLEX; PURINE; STATE; MECHANISM; TOOL;
D O I：
10.1039/b919364b
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An efficient two-step, one-pot, biotransformation involving the fluorinase enzyme is described for the synthesis of 5-deoxy-5[F-18]fluororibose, a novel [F-18]-fluorinated sugar suitable for positron emission tomography (PET) applications.
引用
收藏
页码：139 / 141
页数：3
相关论文
共 13 条
  • [1] The first enzymatic method for C-18F bond formation:: the synthesis of 5′-[18F]-fluoro-5′deoxyadenosine for imaging with PET
    Martarello, L
    Schaffrath, C
    Deng, H
    Gee, AD
    Lockhart, A
    O'Hagan, D
    JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2003, 46 (13) : 1181 - 1189
  • [2] Tumour imaging by Positron Emission Tomography using fluorinase generated 5-[18F]fluoro-5-deoxyribose as a novel tracer
    Dall'Angelo, Sergio
    Bandaranayaka, Nouchali
    Windhorst, Albert D.
    Vugts, Danielle J.
    van der Born, Dion
    Onega, Mayca
    Schweiger, Lutz F.
    Zanda, Matteo
    O'Hagan, David
    NUCLEAR MEDICINE AND BIOLOGY, 2013, 40 (04) : 464 - 470
  • [3] A New Class of Fluorinated A2A Adenosine Receptor Agonist with Application to Last-Step Enzymatic [18F]Fluorination for PET Imaging
    Lowe, Phillip T.
    Dall'Angelo, Sergio
    Mulder-Krieger, Thea
    IJzerman, Adriaan P.
    Zanda, Matteo
    O'Hagan, David
    CHEMBIOCHEM, 2017, 18 (21) : 2156 - 2164
  • [4] Longitudinal flortaucipir ([18F]AV-1451) PET imaging in primary progressive apraxia of speech
    Utianski, Rene L.
    Martin, Peter R.
    Botha, Hugo
    Schwarz, Christopher G.
    Duffy, Joseph R.
    Petersen, Ronald C.
    Knopman, David S.
    Clark, Heather M.
    Butts, Alissa M.
    Machulda, Mary M.
    Jack, Clifford R., Jr.
    Lowe, Val J.
    Whitwell, Jennifer L.
    Josephs, Keith A.
    CORTEX, 2020, 124 : 33 - 43
  • [5] Utility of [18F]2-Fluoro-2-Deoxyglucose-PET in Sporadic and Tuberous Sclerosis-Associated Lymphangioleiomyomatosis
    Young, Lisa R.
    Franz, David N.
    Nagarkatte, Preeti
    Fletcher, Christopher D. M.
    Wikenheiser-Brokamp, Kathryn A.
    Galsky, Matthew D.
    Corbridge, Thomas C.
    Lam, Anna P.
    Gelfand, Michael J.
    McCormack, Francis X.
    CHEST, 2009, 136 (03) : 926 - 933
  • [6] [18F]-THK5351 PET Imaging in Patients With Semantic Variant Primary Progressive Aphasia
    Lee, Hyon
    Seo, Seongho
    Lee, Sang-Yoon
    Jeong, Hye Jin
    Woo, Sung-Ho
    Lee, Kyoung-Min
    Lee, Yeong-Bae
    Park, Kee Hyung
    Heo, Jae-Hyeok
    Yoon, Cindy W.
    Kang, Jae Myeong
    Cho, Jaelim
    Okamura, Nobuyuki
    Furumoto, Shozo
    Yanai, Kazuhiko
    Na, Duk L.
    Ido, Tatsuo
    Villemagne, Victor L.
    Noh, Young
    ALZHEIMER DISEASE & ASSOCIATED DISORDERS, 2018, 32 (01) : 62 - 69
  • [7] Comparison of [18F]FDG PET/CT with magnetic resonance imaging for the assessment of human brown adipose tissue activity
    Fischer, Jonas Gabriel William
    Maushart, Claudia Irene
    Becker, Anton S.
    Mueller, Julian
    Madoerin, Philipp
    Chirindel, Alin
    Wild, Damian
    ter Voert, Edwin E. G. W.
    Bieri, Oliver
    Burger, Irene
    Betz, Matthias Johannes
    EJNMMI RESEARCH, 2020, 10 (01)
  • [8] Assessment of the Incremental Diagnostic Value of Florbetapir F 18 Imaging in Patients With Cognitive Impairment The Incremental Diagnostic Value of Amyloid PET With [18F]-Florbetapir (INDIA-FBP) Study
    Boccardi, Marina
    Altomare, Daniele
    Ferrari, Clarissa
    Festari, Cristina
    Guerra, Ugo Paolo
    Paghera, Barbara
    Pizzocaro, Claudio
    Lussignoli, Giulia
    Geroldi, Cristina
    Zanetti, Orazio
    Cotelli, Maria Sofia
    Turla, Marinella
    Borroni, Barbara
    Rozzini, Luca
    Mirabile, Dario
    Defanti, Carlo
    Gennuso, Michele
    Prelle, Alessandro
    Gentile, Simona
    Morandi, Alessandro
    Vollaro, Stefano
    Dalla Volta, Giorgio
    Bianchetti, Angelo
    Conti, Marta Zaffira
    Cappuccio, Melania
    Carbone, Pasqualina
    Bellandi, Daniele
    Abruzzi, Luciano
    Bettoni, Luigi
    Villani, Daniele
    Raimondi, Maria Clara
    Lanari, Alessia
    Ciccone, Alfonso
    Facchi, Emanuela
    Di Fazio, Ignazio
    Rozzini, Renzo
    Boffelli, Stefano
    Manzoni, Laura
    Salvi, Giovanni Pietro
    Cavaliere, Sabina
    Belotti, Gloria
    Avanzi, Stefano
    Pasqualetti, Patrizio
    Muscio, Cristina
    Padovani, Alessandro
    Frisoni, Giovanni B.
    JAMA NEUROLOGY, 2016, 73 (12) : 1417 - 1424
  • [9] Evaluation of Intraperitoneal [18F]-FDOPA Administration for Micro-PET Imaging in Mice and Assessment of the Effect of Subchronic Ketamine Dosing on Dopamine Synthesis Capacity
    Halff, Els F.
    Natesan, Sridhar
    Bonsall, David R.
    Veronese, Mattia
    Garcia-Hidalgo, Anna
    Kokkinou, Michelle
    Tang, Sac-Pham
    Riggall, Laura J.
    Gunn, Roger N.
    Irvine, Elaine E.
    Withers, Dominic J.
    Wells, Lisa A.
    Howes, Oliver D.
    MOLECULAR IMAGING, 2022, 2022
  • [10] Comprehensive meta-analysis on [18F] FDG PET/CT and radiolabelled leukocyte SPECT-SPECT/CT imaging in infectious endocarditis and cardiovascular implantable electronic device infections
    Cantoni, Valeria
    Sollini, Martina
    Green, Roberta
    Berchiolli, Raffaella
    Lazzeri, Elena
    Mannarino, Teresa
    Acampa, Wanda
    Erba, Paola Anna
    CLINICAL AND TRANSLATIONAL IMAGING, 2018, 6 (01) : 3 - 18
12