Association between alcohol consumption during pregnancy and risks of congenital heart defects in offspring: meta-analysis of epidemiological observational studies

被引：21

作者：

Wen, Zhongyuan ^{[1
]}

Yu, Di ^{[1
]}

Zhang, Weiyan ^{[1
]}

Fan, Changfeng ^{[1
]}

Hu, Liang ^{[1
]}

Feng, Yu ^{[1
]}

Yang, Lei ^{[1
]}

Wu, Zeyu ^{[1
]}

Chen, Runsen ^{[1
]}

Yin, Ke-jie ^{[2
]}

Mo, Xuming ^{[1
]}

机构：

[1] Nanjing Med Univ, Nanjing Childrens Hosp, Dept Cardiothorac Surg, Nanjing 210008, Jiangsu, Peoples R China

[2] Washington Univ, Sch Med, Dept Neurol, Ctr Study Nervous Syst Injury, St Louis, MO 63110 USA

来源：

ITALIAN JOURNAL OF PEDIATRICS | 2016年 / 42卷

基金：

美国国家科学基金会;

关键词：

Congenital heart defects; Alcohol drinking; Pregnancy; Meta-analysis; LIFE-STYLE FACTORS; MATERNAL SMOKING; DOWN-SYNDROME; MALFORMATIONS; SUPPLEMENTS; EXPOSURE; INFANTS;

D O I：

10.1186/s13052-016-0222-2

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Background: To explore the association between maternal alcohol consumption and/or binge drinking and congenital heart defects (CHDs), we conducted a meta-analysis for more sufficient evidence on this issue. Methods: We searched Medline, EMBASE, and the Cochrane Library from their inceptions to December 2014 for case-control and cohort studies that assessed the association between maternal alcohol consumption and CHD risk. Study-specific relative risk estimates were calculated using random-effect or fixed-effect models. Results: A total of 19 case-control studies and 4 cohort studies were included in the meta-analysis. We observed a null association between maternal alcohol consumption during pregnancy and the risk of CHDs. Even in the analysis of different trimesters of pregnancy, we found little association between the two. Conclusions: This meta-analysis suggests that maternal alcohol consumption is modestly not associated with the risk of CHDs. However, further investigation is needed to confirm this conclusion.

引用

页数：11

共 43 条

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