Neuroinflammation in Alzheimer's Disease: Microglia, Molecular Participants and Therapeutic Choices

被引：47

作者：

Wang, Haijun ^{[1
]}

Shen, Yin ^{[1
]}

Chuang, Haoyu ^{[2
,3
,5
]}

Chiu, Chengdi ^{[4
,5
]}

Ye, Youfan ^{[6
]}

Zhao, Lei ^{[7
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Neurosurg, Wuhan, Hubei, Peoples R China

[2] Tainan Municipal An Nan Hosp, Dept Neurosurg, Tainan, Taiwan

[3] China Med Univ, Bei Gang Hosp, Dept Neurosurg, Beigang Township, Yunlin, Taiwan

[4] China Med Univ Hosp, Dept Neurosurg, Taichung, Taiwan

[5] China Med Univ, Sch Med, Taichung, Taiwan

[6] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Ophthalmol, Wuhan, Hubei, Peoples R China

[7] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Infect Dis, Wuhan, Hubei, Peoples R China

来源：

CURRENT ALZHEIMER RESEARCH | 2019年 / 16卷 / 07期

基金：

中国国家自然科学基金;

关键词：

Alzheimer's disease; neuroinflammation; microglia; beta-amyloid; dementia; chemokinases; GROWTH-FACTOR-BETA; MILD COGNITIVE IMPAIRMENT; MESSENGER-RNA EXPRESSION; NECROSIS-FACTOR DEATH; AMYLOID PRECURSOR; MOUSE MODEL; QUINOLINIC ACID; ALTERNATIVE ACTIVATION; APOLIPOPROTEIN-E; ANTIINFLAMMATORY CYTOKINE;

D O I：

10.2174/1567205016666190503151648

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Alzheimer's disease is the world's most common dementing illness. It is pathologically characterized by beta-amyloid accumulation, extracellular senile plaques and intracellular neurofibrillary tangles formation, and neuronal necrosis and apoptosis. Neuroinflammation has been widely recognized as a crucial process that participates in AD pathogenesis. In this review, we briefly summarized the involvement of microglia in the neuroinflammatory process of Alzheimer's disease. Its roles in the AD onset and progression are also discussed. Numerous molecules, including interleukins, tumor necrosis factor alpha, chemokines, inflammasomes, participate in the complex process of AD-related neuroinflammation and they are selectively discussed in this review. In the end of this paper from an inflammation-related perspective, we discussed some potential therapeutic choices.

引用

页码：659 / 674

页数：16

共 168 条

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