Dietary vitamin D and cancers of the oral cavity and esophagus

被引：44

作者：

Lipworth, L. ^{[1
,2
,3
]}

Rossi, M. ^{[4
]}

McLaughlin, J. K. ^{[1
,3
,5
]}

Negri, E. ^{[4
]}

Talamini, R. ^{[6
]}

Levi, F. ^{[7
,8
]}

Franceschi, S. ^{[9
]}

La Vecchia, C. ^{[3
,4
,5
,10
]}

机构：

[1] Int Epidemiol Inst, Rockville, MD 20850 USA

[2] Vanderbilt Univ, Med Ctr, Dept Prevent Med, Nashville, TN USA

[3] Vanderbilt Ingram Canc Ctr, Nashville, TN USA

[4] Inst Pharmacol Res Mario Negri, Dept Epidemiol, Milan, Italy

[5] Vanderbilt Univ, Med Ctr, Dept Med, Nashville, TN USA

[6] Oncol Referral Ctr, Epidemiol & Biostat Unit, Aviano, PN, Italy

[7] Univ Lausanne, Inst Social & Prevent Med, Canc Epidemiol Unit, Lausanne, Switzerland

[8] Univ Lausanne, Inst Social & Prevent Med, Lausanne, Switzerland

[9] Int Agcy Res Canc, Epidemiol & Biol Cluster, F-69372 Lyon, France

[10] Univ Milan, Inst Med Stat & Biometr G A Maccacaro, Milan, Italy

来源：

ANNALS OF ONCOLOGY | 2009年 / 20卷 / 09期

关键词：

cancer; epidemiology; esophageal; oral; pharyngeal; vitamin D; FOOD-FREQUENCY QUESTIONNAIRE; NONMELANOMA SKIN-CANCER; UNITED-STATES; MORTALITY RATES; B RADIATION; RISK; COLON; REPRODUCIBILITY; SUNLIGHT; HEALTH;

D O I：

10.1093/annonc/mdp036

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Methods: In two case-control studies in Italy, we examined the relation between dietary vitamin D intake and squamous cell carcinoma of the esophagus (SCCE; 304 cases) and oral/pharyngeal cancer (804 cases). Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by multiple logistic regression. Results: Adjusted ORs for SCCE and oral/pharyngeal cancer were 0.58 (95% CI 0.39-0.86) and 0.76 (95% CI 0.60-0.94), respectively, for the highest tertile of vitamin D intake. Using a reference group of those in the highest tertile of vitamin D who were never/former smokers, ORs were 8.7 (95% CI 4.1-18.7) for SCCE and 10.4 (95% CI 6.9-15.5) for oral/pharyngeal cancer among heavy smokers in the lowest vitamin D tertile; similarly, compared with those in the highest tertile of vitamin D who drank < 3 alcoholic drinks/day, corresponding ORs were 41.9 (95% CI 13.7-128.6) for SCCE and 8.5 (95% CI 5.7-12.5) for oral/pharyngeal cancer, among heavy alcohol drinkers in the lowest vitamin D tertile. Conclusion: We observed inverse associations between dietary vitamin D intake and risk of SCCE and, perhaps, oral/pharyngeal cancer, which were most pronounced among heavy current smokers and heavy consumers of alcohol.

引用

页码：1576 / 1581

页数：6

共 39 条

[1] Serum 25(OH)-Vitamin D concentration and risk of esophageal squamous dysplasia [J].