Influenza vaccination reduces incidence of peripheral arterial occlusive disease in elderly patients with chronic kidney disease

被引：6

作者：

Hu, Ping-Jen ^{[1
,2
]}

Chen, Chia-Hsien ^{[3
,4
,5
]}

Wong, Chung-Shun ^{[6
,7
,8
]}

Chen, Tzu-Ting ^{[9
,10
]}

Wu, Mei-Yi ^{[9
,11
,12
,13
,14
]}

Sung, Li-Chin ^{[11
,15
,16
,17
]}

机构：

[1] Taitung Mackay Mem Hosp, Div Gastroenterol & Hepatol, Dept Internal Med, Taitung, Taiwan

[2] Taipei Med Univ, Shuang Ho Hosp, Div Gastroenterol, Dept Internal Med, New Taipei, Taiwan

[3] Taipei Med Univ, Shuang Ho Hosp, Dept Orthoped, New Taipei, Taiwan

[4] Taipei Med Univ, Sch Med, Dept Orthoped Surg, Coll Med, Taipei, Taiwan

[5] Taipei Med Univ, Sch Biomed Engn, Coll Biomed Engn, Taipei, Taiwan

[6] Taipei Med Univ, Grad Inst Clin Med, Coll Med, Taipei, Taiwan

[7] Taipei Med Univ, Shuang Ho Hosp, Emergency Dept, New Taipei, Taiwan

[8] Taipei Med Univ, Sch Med, Dept Emergency, Coll Med, Taipei, Taiwan

[9] Natl Taiwan Univ, Coll Publ Hlth, Inst Epidemiol & Prevent Med, Taipei, Taiwan

[10] Natl Hlth Res Inst, Ctr Neuropsychiat Res, Miaoli, Taiwan

[11] Taipei Med Univ, Shuang Ho Hosp, Dept Primary Care Med, New Taipei, Taiwan

[12] Taipei Med Univ, Sch Med, Coll Med, Div Nephrol,Dept Internal Med, Taipei, Taiwan

[13] Taipei Med Univ, Shuang Ho Hosp, Dept Internal Med, Div Nephrol, New Taipei, Taiwan

[14] Taipei Med Univ, TMU Res Ctr Urol & Kidney, Taipei, Taiwan

[15] Taipei Med Univ, Sch Med, Dept Internal Med, Coll Med,Div Cardiol, Taipei, Taiwan

[16] Taipei Med Univ, Shuang Ho Hosp, Dept Internal Med, Div Cardiol, New Taipei, Taiwan

[17] Taipei Med Univ, Taipei Heart Inst, Taipei, Taiwan

来源：

SCIENTIFIC REPORTS | 2021年 / 11卷 / 01期

关键词：

GLOMERULAR-FILTRATION-RATE; VASCULAR-DISEASE; NATIONAL-HEALTH; HIGH PREVALENCE; RISK; CORONARY; ASSOCIATION; RATIONALE; MORBIDITY; DESIGN;

D O I：

10.1038/s41598-021-84285-8

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

An influenza vaccination might reduce the risk of incident peripheral arterial occlusive disease (PAOD) in patients with chronic kidney disease (CKD), but supporting evidence is limited. This case-crossover study analyzed data from Taiwan's real-world National Health Insurance Research Database. This study included elderly (>= 67 years old) patients with CKD having incident PAOD from January 1, 2006, to June 30, 2015. We defined 1 year before PAOD onset as the index date for the self-control group. A conditional logistic regression model was used to investigate exposure to an influenza vaccination for estimating the risk for incident PAOD following vaccination. In total, this study included 46,782 elderly patients with CKD having incident PAOD. The odds ratios for incident PAOD were 0.85 (95% confidence interval 0.77-0.94), 0.85 (0.79-0.92), 0.84 (0.79-0.90), and 0.85 (0.81-0.90) at 1, 2, 3, and 4 months after an influenza vaccination, respectively. We observed consistent results for the subgroups of patients with CKD and concomitant diabetes. However, we did not observe any beneficial effects of influenza vaccination in patients with advanced CKD or end-stage renal disease. This study demonstrated that influenza vaccination may be associated with a reduced risk of incident PAOD among patients with early-stage CKD.

引用

页数：8

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[31] THE CASE-CROSSOVER DESIGN - A METHOD FOR STUDYING TRANSIENT EFFECTS ON THE RISK OF ACUTE EVENTS [J].