Autoxidation/Aldol Tandem Reaction of 2-Oxindoles with Ketones: A Green Approach for the Synthesis of 3-Hydroxy-2-Oxindoles

被引：18

作者：

Zhang, Qing-Bao ^{[1
]}

Jia, Wen-Liang ^{[1
]}

Ban, Yong-Liang ^{[1
]}

Zheng, Yong ^{[1
]}

Liu, Qiang ^{[1
]}

Wu, Li-Zhu ^{[2
]}

机构：

[1] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

[2] Chinese Acad Sci, Tech Inst Phys & Chem, Key Lab Photochem Convers & Optoelect Mat, Beijing 100864, Peoples R China

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2016年 / 22卷 / 08期

关键词：

autoxidation; C-H activation; oxindoles; oxygen; tetrabutylammonium fluoride; MOLECULAR-OXYGEN; SELECTIVE AUTOXIDATION; TERMINAL ALKYNES; CATALYZED OXIDATION; SINGLET OXYGEN; BOND-CLEAVAGE; LEWIS-ACID; OXINDOLES; HYDROXYLATION; ESTERS;

D O I：

10.1002/chem.201504282

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In the presence of tetrabutylammonium fluoride and molecular sieves (MS) 4 angstrom in DMF, an efficient autoxidation reaction of 2-oxindoles with ketones under air at room temperature has been developed. This approach may provide a green, practical, and metal-free protocol for a wide range of biologically important 3-hydroxy-3-(2-oxo-alkyl)-2-oxindoles.

引用

页码：2595 / 2598

页数：4

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