Dragmacidin F:: A new antiviral bromoindole alkaloid from the mediterranean sponge Halicortex sp.

被引：98

作者：

Cutignano, A ^{[1
]}

Bifulco, G ^{[1
]}

Bruno, I ^{[1
]}

Casapullo, A ^{[1
]}

Gomez-Paloma, L ^{[1
]}

Riccio, R ^{[1
]}

机构：

[1] Univ Salerno, Dipartimento Sci Farmaceut, I-84084 Salerno, Italy

来源：

TETRAHEDRON | 2000年 / 56卷 / 23期

关键词：

alkaloids; antivirals; indoles; marine metabolites;

D O I：

10.1016/S0040-4020(00)00281-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new bromoindole alkaloid, named dragmacidin F (1) and structurally related to other dragmacidins previously described, was isolated from a marine sponge of the genus Halicortex collected off the southern coast of Ustica Island (Italy). Structural elucidation of 1 was achieved by an extensive spectroscopic study (mainly by 1D/2D-NMR and MS techniques). Compound 1, containing an unprecedented carbon skeleton that is very likely derived from cyclization of a partially oxidized form of dragmacidin D (2), showed in vitro antiviral activity against HSV-1 (EC50=95.8 mu M) and HIV-1 (EC50=0.91 mu M), thus proving to be responsible for the antiviral property exhibited by Halicortex extracts. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：3743 / 3748

页数：6

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