Dragmacidin F:: A new antiviral bromoindole alkaloid from the mediterranean sponge Halicortex sp.

被引：98
|
作者：
Cutignano, A [1 ]
Bifulco, G [1 ]
Bruno, I [1 ]
Casapullo, A [1 ]
Gomez-Paloma, L [1 ]
Riccio, R [1 ]
机构：
[1] Univ Salerno, Dipartimento Sci Farmaceut, I-84084 Salerno, Italy
来源：
TETRAHEDRON | 2000年 / 56卷 / 23期
关键词：
alkaloids; antivirals; indoles; marine metabolites;
D O I：
10.1016/S0040-4020(00)00281-7
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new bromoindole alkaloid, named dragmacidin F (1) and structurally related to other dragmacidins previously described, was isolated from a marine sponge of the genus Halicortex collected off the southern coast of Ustica Island (Italy). Structural elucidation of 1 was achieved by an extensive spectroscopic study (mainly by 1D/2D-NMR and MS techniques). Compound 1, containing an unprecedented carbon skeleton that is very likely derived from cyclization of a partially oxidized form of dragmacidin D (2), showed in vitro antiviral activity against HSV-1 (EC50=95.8 mu M) and HIV-1 (EC50=0.91 mu M), thus proving to be responsible for the antiviral property exhibited by Halicortex extracts. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：3743 / 3748
页数：6
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