Archeal lectins: An identification through a genomic search

被引:12
作者
Abhinav, K. V. [1 ]
Samuel, Ebenezer [1 ]
Vijayan, M. [1 ]
机构
[1] Indian Inst Sci, Mol Biophys Unit, Bangalore 560012, Karnataka, India
关键词
lectin homologues; microbial lectins; domain identification; 7-bladed -propeller fold; -trefoil; evolutionary implications; BETA-PRISM FOLD; CRYSTAL-STRUCTURE; CARBOHYDRATE-BINDING; STRUCTURAL BASIS; INNATE IMMUNITY; EVOLUTIONARY IMPLICATIONS; QUATERNARY ASSOCIATION; LIGAND SPECIFICITY; ANTIVIRAL PROTEIN; CHOLERA-TOXIN;
D O I
10.1002/prot.24949
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Forty-six lectin domains which have homologues among well established eukaryotic and bacterial lectins of known three-dimensional structure, have been identified through a search of 165 archeal genomes using a multipronged approach involving domain recognition, sequence search and analysis of binding sites. Twenty-one of them have the 7-bladed -propeller lectin fold while 16 have the -trefoil fold and 7 the legume lectin fold. The remainder assumes the C-type lectin, the -prism I and the tachylectin folds. Acceptable models of almost all of them could be generated using the appropriate lectins of known three-dimensional structure as templates, with binding sites at one or more expected locations. The work represents the first comprehensive bioinformatic study of archeal lectins. The presence of lectins with the same fold in all domains of life indicates their ancient origin well before the divergence of the three branches. Further work is necessary to identify archeal lectins which have no homologues among eukaryotic and bacterial species. Proteins 2016; 84:21-30. (c) 2015 Wiley Periodicals, Inc.
引用
收藏
页码:21 / 30
页数:10
相关论文
共 56 条
[1]   Identification of mycobacterial lectins from genomic data [J].
Abhinav, K. V. ;
Sharma, Alok ;
Vijayan, M. .
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2013, 81 (04) :644-657
[2]   Structural diversity and ligand specificity of lectins. The Bangalore effort [J].
Abhinav, Koyamangalath Vadakkepat ;
Vijayan, Mamannamana .
PURE AND APPLIED CHEMISTRY, 2014, 86 (09) :1335-1355
[3]   Gapped BLAST and PSI-BLAST: a new generation of protein database search programs [J].
Altschul, SF ;
Madden, TL ;
Schaffer, AA ;
Zhang, JH ;
Zhang, Z ;
Miller, W ;
Lipman, DJ .
NUCLEIC ACIDS RESEARCH, 1997, 25 (17) :3389-3402
[4]  
[Anonymous], PYMOL MOL GRAPH SYST
[5]   Tachylectin-2:: crystal structure of a specific GlcNAc/GalNAc-binding lectin involved in the innate immunity host defense of the Japanese horseshoe crab Tachypleus tridentatus [J].
Beisel, HG ;
Kawabata, S ;
Iwanaga, S ;
Huber, R ;
Bode, W .
EMBO JOURNAL, 1999, 18 (09) :2313-2322
[6]   Carbohydrate-binding modules: fine-tuning polysaccharide recognition [J].
Boraston, AB ;
Bolam, DN ;
Gilbert, HJ ;
Davies, GJ .
BIOCHEMICAL JOURNAL, 2004, 382 (03) :769-781
[7]   The structure of a PKD domain from polycystin-1: Implications for polycystic kidney disease [J].
Bycroft, M ;
Bateman, A ;
Clarke, J ;
Hamill, SJ ;
Sandford, R ;
Thomas, RL ;
Chothia, C .
EMBO JOURNAL, 1999, 18 (02) :297-305
[8]   MatGAT: An application that generates similarity/identity matrices using protein or DNA sequences [J].
Campanella, JJ ;
Bitincka, L ;
Smalley, J .
BMC BIOINFORMATICS, 2003, 4 (1)
[9]   Generation of Ligand Specificity and Modes of Oligomerization in β-Prism I Fold Lectins [J].
Chandran, Thyageshwar ;
Sharma, Alok ;
Vijayan, Mamannamana .
DYNAMICS OF PROTEINS AND NUCLEIC ACIDS, 2013, 92 :135-178
[10]   β-propeller crystal structure of Psathyrella velutina lectin:: An integrin-like fungal protein interacting [J].
Cioci, G ;
Mitchell, EP ;
Chazalet, V ;
Debray, H ;
Oscarson, S ;
Lahmann, M ;
Gautier, C ;
Breton, C ;
Perez, S ;
Imberty, A .
JOURNAL OF MOLECULAR BIOLOGY, 2006, 357 (05) :1575-1591