Effects of the Bragg peak degradation due to lung tissue in proton therapy of lung cancer patients

被引：20

作者：

Baumann, Kilian-Simon ^{[1
,2
]}

Flatten, Veronika ^{[1
,2
]}

Weber, Uli ^{[3
]}

Lautenschlaeger, Stefan ^{[1
,4
]}

Eberle, Fabian ^{[1
,4
]}

Zink, Klemens ^{[1
,2
,5
]}

Engenhart-Cabillic, Rita ^{[1
,4
]}

机构：

[1] Univ Med Ctr Giessen Marburg, Dept Radiotherapy & Radiooncol, Marburg, Germany

[2] Univ Appl Sci, Inst Med Phys & Radiat Protect, Giessen, Germany

[3] GSI Helmholtzzentrum Schwerionenforsch, Biophys Div, Darmstadt, Germany

[4] Marburg Ion Beam Therapy Ctr MIT, Marburg, Germany

[5] FIAS, Frankfurt, Germany

来源：

RADIATION ONCOLOGY | 2019年 / 14卷 / 01期

关键词：

Proton therapy; Lung modulation; Bragg peak degradation; Treatment planning; MONTE-CARLO; STAGE-I; RANGE UNCERTAINTIES; RADIATION-THERAPY; BEAM THERAPY; MOTION; RADIOTHERAPY; INTERPLAY; CT; DISTRIBUTIONS;

D O I：

10.1186/s13014-019-1375-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose To quantify the effects of the Bragg peak degradation due to lung tissue on treatment plans of lung cancer patients with spot scanning proton therapy and to give a conservative approximation of these effects. Methods and materials Treatment plans of five lung cancer patients (tumors of sizes 2.7-46.4 cm(3) at different depths in the lung) were optimized without consideration of the Bragg peak degradation. These treatment plans were recalculated with the Monte Carlo code TOPAS in two scenarios: in a first scenario, the treatment plans were calculated without including the Bragg peak degradation to reproduce the dose distribution predicted by the treatment-planning system (TPS). In a second scenario, the treatment plans were calculated while including the Bragg peak degradation. Subsequently, the plans were compared by means of D-mean, D-98% and D-2% in the clinical target volume (CTV) and organs at risk (OAR). Furthermore, isodose lines were investigated and a gamma index analysis was performed. Results The Bragg peak degradation leads to a lower dose in the CTV and higher doses in OARs distal to the CTV compared to the prediction from the TPS. The reduction of the mean dose in the CTV was - 5% at maximum and - 2% on average. The deeper a tumor was located in the lung and the smaller its volume the bigger was the effect on the CTV. The enhancement of the mean dose in OARs distal to the CTV was negligible for the cases investigated. Conclusions Effects of the Bragg peak degradation due to lung tissue were investigated for lung cancer treatment plans in proton therapy. This study confirms that these effects are clinically tolerable to a certain degree in the current clinical context considering the various more critical dose uncertainties due to motion and range uncertainties in proton therapy.

引用

页数：15