Biodegradable Scaffolds for Urethra Tissue Engineering Based on 3D Printing

被引：23

作者：

Xu, Yifan ^{[1
]}

Meng, Qinghua ^{[1
]}

Jin, Xin ^{[1
]}

Liu, Feng ^{[2
]}

Yu, Jianjun ^{[2
,3
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Shanghai 200240, Peoples R China

[2] Shanghai Fengxian Dist Cent Hosp, Shanghai 201400, Peoples R China

[3] Zhejiang Univ, Affiliated Hosp 1, Hangzhou 310003, Peoples R China

来源：

ACS APPLIED BIO MATERIALS | 2020年 / 3卷 / 04期

关键词：

tissue engineering; 3D printing; sacrificial template; biodegradable materials; biocompatibility; LINGUAL MUCOSAL GRAFT; VASCULAR NETWORKS; URETHROPLASTY; RECONSTRUCTION; DEGRADATION; COPOLYMER; MATRIX; CHAIN; PLGA;

D O I：

10.1021/acsabm.9b01151

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Tissue engineering scaffolds are used to repair urethra universally, whereas few of those methods could fit the specific shape of the patient's lesion. Here a election of biodegradable polymers were made, and then an economic, biodegradable, modified material PLGA/PCL/TEC 70:30:6 with good biocompatibility and mechanical properties was prepared. A method for customized tissue engineering scaffolds based on 3D printing technology was established. Based on medical image data, three-dimensional template models were built up with a certain process for 3D printing. Customized scaffolds can be prepared by coating the printed template with modified material and removing the inner template. L929 was selected as the cell model to observe cytotoxicity and cell adhesion on materials' films. The prepared scaffolds were assessed by scanning electron microscopy and degradation in vitro to verify the feasibility as urethra for issue engineering.

引用

页码：2007 / 2016

页数：10

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