The analytical profile of some 4-methylthioamphetamine (4-MTA) homologues

被引：5

作者：

Blachut, Dariusz ^{[1
]}

Wojtasiewicz, Krystyna ^{[2
]}

Czarnocki, Zbigniew ^{[2
]}

Szukalski, Bogdan ^{[3
]}

机构：

[1] Internal Secur Agcy, Forens Lab, PL-02134 Warsaw, Poland

[2] Warsaw Univ, Fac Chem, PL-02093 Warsaw, Poland

[3] Inst Psychiat & Neurol, PL-02957 Warsaw, Poland

来源：

FORENSIC SCIENCE INTERNATIONAL | 2009年 / 192卷 / 1-3期

关键词：

4-Methylthiophenylisopropylamine; Amphetamines; Mass spectrometry; Forensic analysis; Gas chromatography; DESIGNER DRUG 4-METHYLTHIOAMPHETAMINE; MASS-SPECTRAL ANALYSIS; N-SUBSTITUTED ANALOGS; GC-MS ANALYSIS; P-METHYLTHIOAMPHETAMINE; ACYLATED DERIVATIVES; HUMAN URINE; IDENTIFICATION; 4-METHOXYAMPHETAMINE; METHAMPHETAMINE;

D O I：

10.1016/j.forsciint.2009.08.009

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

The 4-methylthioamphetamine (4-MTA) is a sulphur-containing amphetamine-type stimulant (ATS), which appeared on the illicit market in Europe at the end of 90s. For the purpose of this study, several N-alkyl homologues of 4-MTA, including 4-methylthiomethamphetamine (4-MTMA), 4-methylthioethylamphetamine (4-MTEA), 4-methylthiodimethamphetamine (4-MTDMA), 4-methylthiopropylamphetamine (4-MTPA) and 4-methylthiobutylamphetamine (4-MTBA) were synthesized. The homologues were characterized by means of gas chromatography/mass spectrometry (GC-MS), infrared (IR) spectroscopy and the magnetic resonance spectroscopy (H-1 and C-13 NMR). The gas chromatography and mass spectrometry properties of their acetyl, trifluoroacyl (TFA), pentafluoropropionyl (PFP) and heptafluorobutyryl (HFB) derivatives were also investigated and discussed. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

引用

页码：98 / 114

页数：17

共 41 条

[1]

[Anonymous], 1997, PIHKAL CHEM LOVE STO

[2] MASS-SPECTRA OF DIMETHOXYAMPHETAMINE HYDROCHLORIDES [J].

BAILEY, K .

ANALYTICA CHIMICA ACTA, 1972, 60 (02) :287-&

[3] Identification of N-methyl-1-(1,3-benzodioxol-5-yl)-2-butanamine (MBDB), an homologue derivative of "ecstasy" [J].

Baudot, P ;

Vicherat, A ;

Viriot, ML ;

Carré, MC .

ANALUSIS, 1999, 27 (06) :523-532

[4] GC-MS studies on acylated derivatives of 3-methoxy-4-methyl- and 4-methoxy-3-methyl-phenethylamines: Regioisomers related to 3,4-MDMA [J].

Belal, Tarek ;

Awad, Tamer ;

DeRuiter, Jack ;

Clark, C. Randall .

FORENSIC SCIENCE INTERNATIONAL, 2008, 178 (01) :61-82

[5]

Biemann K., 1962, MASS SPECTROMETRY OR

[6] Identification and synthesis of some contaminants present in 4-methoxyamphetamine (PMA) prepared by the Leuckart method [J].

Blachut, D ;

Wojtasiewicz, K ;

Czarnocki, Z .

FORENSIC SCIENCE INTERNATIONAL, 2002, 127 (1-2) :45-62

[7] CYANOHYDRIDOBORATE ANION AS A SELECTIVE REDUCING AGENT [J].

BORCH, RF ;

BERNSTEIN, MD ;

DURST, HD .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1971, 93 (12) :2897-+

[8]

BOSMAN IJ, 2000, PROB FORENSIC SCI, V43, P51

[9]

BOSMAN IJ, 2000, PROB FORENSIC SCI, V42, P215

[10] Comparative metabolism of the designer drug 4-methylthioamphetamine by hepatocytes from man, monkey, dog, rabbit, rat and mouse [J].

Carmo, H ;

Hengstler, JG ;

de Boer, D ;

Ringel, M ;

Carvalho, F ;

Fernandes, E ;

Remiao, F ;

dos Reys, LA ;

Oesch, F ;

Bastos, MD .

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2004, 369 (02) :198-205

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