Relationship between vitamin D, IFN-γ, and E2 levels in systemic lupus erythematosus

被引：18
作者：
Kokic, V. [1 ]
Kaliterna, D. Martinovic [2 ]
Radic, M. [2 ]
Perkovic, D. [2 ]
Cvek, M. [3 ]
Capkun, V. [3 ]
机构：
[1] Univ Hosp Split, Div Endocrinol Diabet & Metab Dis, Split 21000, Croatia
[2] Univ Hosp Split, Div Rheumatol & Clin Immunol, Sizgoriceva 20, Split 21000, Croatia
[3] Univ Hosp Split, Div Nucl Med, Split 21000, Croatia
来源：
LUPUS | 2016年 / 25卷 / 03期
关键词：
Systemic lupus erythematosus; vitamin D; interferon-gamma; estradiol; INTERFERON-GAMMA; D DEFICIENCY; CELLS; SLE; BALANCE;
D O I：
10.1177/0961203315605367
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In this study, we investigated the relationship between vitamin D, interferon-gamma (IFN-gamma), and estradiol (E-2) in females of childbearing age with inactive systemic lupus erythematosus (SLE). The study included 22 SLE patients, and 21 age-and gender-matched healthy individuals. Serum concentrations of 25-hydroxyvitamin D-3 (25(OH)D-3), E-2, and IFN-gamma were measured by radioimmunoassay using the gamma-counter and ELISA. Patients and control subjects were divided into two groups based on their vitamin D levels (25(OH) D-3 <= 20 ng/mL; 25(OH)D-3 <= 20 ng/mL). The median values of IFN-gamma and E-2 were higher in SLE patients compared to the controls, irrespective of vitamin D level (p = 0.001, p = 0.009, p = 0.003, and p = 0.003, respectively). In SLE patients, there was a negative correlation between IFN-gamma and 25(OH)D-3 (r(s) = -0.330; p = 0.03) and a positive correlation between IFN-gamma and E-2 (r(s) = 0.404; p = 0.007). This study demonstrates an interesting interplay between vitamin D, INF-gamma, and E-2 in SLE patients with inactive disease.
引用
收藏
页码：282 / 288
页数：7
相关论文
共 31 条
[1]  
Akahoshi M, 1999, ARTHRITIS RHEUM, V42, P1644, DOI 10.1002/1529-0131(199908)42:8<1644::AID-ANR12>3.0.CO
[2]  
2-L
[3]   Serum concentrations of 25-OH vitamin D in patients with systemic lupus erythematosus (SLE) are inversely related to disease activity: is it time to routinely supplement patients with SLE with vitamin D? [J].
Amital, H. ;
Szekanecz, Z. ;
Szucs, G. ;
Danko, K. ;
Nagy, E. ;
Csepany, T. ;
Kiss, E. ;
Rovensky, J. ;
Tuchynova, A. ;
Kozakova, D. ;
Doria, A. ;
Corocher, N. ;
Agmon-Levin, N. ;
Barak, V. ;
Orbach, H. ;
Zandman-Goddard, G. ;
Shoenfeld, Y. .
ANNALS OF THE RHEUMATIC DISEASES, 2010, 69 (06) :1155-1157
[4]   Interferons as pathogenic effectors in autoimmunity [J].
Baccala, R ;
Kono, DH ;
Theofilopoulos, AN .
IMMUNOLOGICAL REVIEWS, 2005, 204 :9-26
[5]  
BASHAM TY, 1983, J IMMUNOL, V130, P1492
[6]   Vitamin D status in systemic lupus erythematosus patients and its association with selected clinical and laboratory parameters [J].
Bogaczewicz, J. ;
Sysa-Jedrzejowska, A. ;
Arkuszewska, C. ;
Zabek, J. ;
Kontny, E. ;
McCauliffe, D. P. ;
Wozniacka, A. .
LUPUS, 2012, 21 (05) :477-484
[7]   1α,25-dihydroxyvitamin D3 has a direct effect on naive CD4+ T cells to enhance the development of Th2 cells [J].
Boonstra, A ;
Barrat, FJ ;
Crain, C ;
Heath, VL ;
Savelkoul, HFJ ;
O'Garra, A .
JOURNAL OF IMMUNOLOGY, 2001, 167 (09) :4974-4980
[8]   Anti-vitamin D, vitamin D in SLE - Preliminary results [J].
Carvalho, Jozelio Freire ;
Blank, Miri ;
Kiss, Emese ;
Tarr, Tunde ;
Amital, Howard ;
Shoenfeld, Yehuda .
AUTOIMMUNITY, PART A: BASIC PRINCIPLES AND NEW DIAGNOSTIC TOOLS, 2007, 1109 :550-557
[9]   Vitamin D involvement in rheumatoid arthritis and systemic lupus erythaematosus [J].
Cutolo, M. ;
Otsa, K. ;
Paolino, S. ;
Yprus, M. ;
Veldi, T. ;
Seriolo, B. .
ANNALS OF THE RHEUMATIC DISEASES, 2009, 68 (03) :446-447
[10]   T cell cytokine imbalance towards production of IFN-γ and IL-10 in NZB/W F1 lupus-prone mice is associated with autoantibody levels and nephritis [J].
Enghard, P. ;
Langnickel, D. ;
Riemekasten, G. .
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY, 2006, 35 (03) :209-216
1234