Biologic and advanced immunomodulating therapeutic options for sarcoidosis: a clinical update

被引：16

作者：

Obi, Ogugua Ndili ^{[1
]}

Lower, Elyse E. ^{[2
]}

Baughman, Robert P. ^{[2
]}

机构：

[1] East Carolina Univ, Brody Sch Med, Div Pulm Crit Care & Sleep Med, Greenville, NC 27858 USA

[2] Univ Cincinnati, Dept Med, Cincinnati, OH 45221 USA

来源：

EXPERT REVIEW OF CLINICAL PHARMACOLOGY | 2021年 / 14卷 / 02期

关键词：

Sarcoidosis; infliximab; adalimumab; rituximab; repository corticotropin injection; tumor necrosis factor; PLACEBO-CONTROLLED TRIAL; REGULATORY T-CELLS; QUALITY-OF-LIFE; NICOTINIC ACETYLCHOLINE-RECEPTOR; VASOACTIVE-INTESTINAL-PEPTIDE; CHRONIC PULMONARY SARCOIDOSIS; BRONCHOALVEOLAR LAVAGE FLUID; ACTIVE RHEUMATOID-ARTHRITIS; FACTOR-ALPHA PRODUCTION; DOUBLE-BLIND;

D O I：

10.1080/17512433.2021.1878024

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Introduction: Sarcoidosis is a multi-organ disease with a wide range of clinical manifestations and outcomes. A quarter of sarcoidosis patients require long-term treatment for chronic disease. In this group, corticosteroids and cytotoxic agents be insufficient to control disease Areas covered: Several biologic agents have been studied for treatment of chronic pulmonary and extra-pulmonary disease. A review of the available literature was performed searching PubMed and an expert opinion regarding specific therapy was developed. Expert opinion: These agents have the potential of treating patients who have progressive disease. Many of these agents have different mechanisms of action, response rates, and toxicity profiles.

引用

页码：179 / 210

页数：32

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