Organophosphate pesticide exposure among farm women and children: Status of micronutrients, acetylcholinesterase activity, and oxidative stress

被引:12
作者
Medithi, Srujana [1 ,2 ]
Kasa, Yogeswar Dayal [1 ]
Jee, Babban [3 ]
Kodali, Venkaiah [4 ]
Jonnalagadda, Padmaja R. [1 ]
机构
[1] Indian Council Med Res, Natl Inst Nutr, Food Safety Div, Hyderabad 500007, Telangana, India
[2] Symbiosis Int Deemed Univ, Symbiosis Inst Hlth Sci SIHS, Pune, Maharashtra, India
[3] Govt India, Dept Hlth Res, Minist Hlth & Family Welf, New Delhi, India
[4] Indian Council Med Res, Natl Inst Nutr, Biostat Div, Hyderabad, Telangana, India
关键词
Acetylcholinesterase inhibition; farm children; farm women; micronutrient status; oxidative stress; pesticides; BIOCHEMICAL-ALTERATIONS; BLOOD; WORKERS; RESIDUES; TOXICITY; MARKERS; PUNJAB;
D O I
10.1080/19338244.2020.1854646
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Nutritional status plays a major role in determining the possible adverse health outcomes due to pesticide toxicity. The objective of the present study was to assess the organophosphorus pesticide residue levels among farm women (FW) (24-45years) and farm children (FC) (9-12 and 13-15years) belonging to the Rangareddy district (Telangana, India) along with their micronutrient status, inhibition of acetylcholinesterase activity, and oxidative stress levels. Residues of Chlorpyrifos, Diazinon, Malathion, Monocrotophos and Phosalone were found in the serum samples of FW and FC along with significantly low levels of vitamins and minerals. Inhibition of AChE activity was observed in FW and FC and altered oxidative stress parameters among FW. Correlation studies have found significant associations between the pesticide residues, micronutrients and antioxidant enzymes. The study suggests an association between pesticide exposure coupled with micronutrient deficiency, induced AChE inhibition, and oxidative stress.
引用
收藏
页码:109 / 124
页数:16
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