Circulating Progenitor Cells in Patients With Coronary Artery Disease and Renal Insufficiency

被引：9

作者：

Mehta, Anurag ^{[1
]}

Tahhan, Ayman S. ^{[1
]}

Liu, Chang ^{[1
,2
]}

Dhindsa, Devinder S. ^{[1
]}

Nayak, Aditi ^{[1
]}

Hooda, Ananya ^{[1
]}

Moazzami, Kasra ^{[1
]}

Islam, Shabatun J. ^{[1
]}

Rogers, Steven C. ^{[1
]}

Almuwaqqat, Zakaria ^{[1
]}

Mokhtari, Ali ^{[1
]}

Hesaroieh, Iraj ^{[1
]}

Ko, Yi-An ^{[1
,3
]}

Waller, Edmund K. ^{[4
]}

Quyyumi, Arshed A. ^{[1
]}

机构：

[1] Emory Univ, Div Cardiol, Dept Med, Emory Clin Cardiovasc Res Inst,Sch Med, Atlanta, GA 30322 USA

[2] Emory Univ, Dept Epidemiol, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA

[3] Emory Univ, Rollins Sch Publ Hlth, Dept Biostat & Bioinformat, Atlanta, GA 30322 USA

[4] Emory Univ, Sch Med, Dept Hematol & Oncol, Winship Canc Inst, Atlanta, GA USA

来源：

JACC-BASIC TO TRANSLATIONAL SCIENCE | 2020年 / 5卷 / 08期

基金：

美国国家卫生研究院;

关键词：

coronary artery disease; outcomes; progenitor cells; regenerative capacity; renal insufficiency; ENDOTHELIAL-CELLS; CARDIOVASCULAR EVENTS; KIDNEY; DYSFUNCTION; MORTALITY; NUMBER; RISK; STEM;

D O I：

10.1016/j.jacbts.2020.06.006

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Patients with coronary artery disease and renal insufficiency (RI) (estimated glomerular filtration rate <60 mi./ min/1.73 m 2 ) are at an increased risk of cardiovascular events. The contribution of regenerative capacity, measured as circulating progenitor cell (CPC) counts, to this increased risk is unclear. CPCs were enumerated as cluster of differentiation (CD) 45me d + mononuclear cells expressing CD34+, CD133+, CXCR4+ (chemokine [C-X-C motif] receptor 4), and VEGF2R+ (vascular endothelial growth factor receptor 2) epitopes in 1,281 subjects with coronary artery disease (35% with RI). Patients with RI and tow (C) 2020 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.

引用

页码：770 / 782

页数：13

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