Targeted Near-Infrared Fluorescence Imaging With Iodized Indocyanine Green in Preoperative Pulmonary Localization: Comparative Efficacy, Safety, Patient Perception With Hook-Wire Localization

被引:15
作者
Ding, Ning [1 ]
Wang, Kefei [1 ]
Cao, Jian [1 ]
Hu, Ge [2 ]
Wang, Zhiwei [1 ]
Jin, Zhengyu [1 ]
机构
[1] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Radiol, State Key Lab Complex Severe & Rare Dis, Beijing, Peoples R China
[2] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Med Res Ctr, State Key Lab Complex Severe & Rare Dis, Beijing, Peoples R China
来源
FRONTIERS IN ONCOLOGY | 2021年 / 11卷
关键词
pulmonary nodule; hook wire; indocyanine green (ICG); preoperative localization; video-assisted thoracoscopic surgery (VATS); ASSISTED THORACOSCOPIC SURGERY; WEDGE RESECTION; LUNG NODULES; CANCER; BLUE;
D O I
10.3389/fonc.2021.707425
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background Precise preoperative localization is of great importance to improve the success rate and reduce the operation time of VATS surgery. This study aimed to assess the efficacy, safety, patient perception between CT-guided indocyanine green (ICG) preoperative localization of lung nodule and hook-wire localization. Methods 65 patients with 85 clinically suspicious pulmonary nodules underwent ICG preoperative localization in this study, and 92 patients with 95 nodules localized by conventional hook-wire served as controls. Both hook-wire localization and ICG injection were performed under CT guidance. Successful targeting rate, success rate in the operative field, incidence rate of complications and respiratory pain score were recorded and compared. Results The successful targeting rate for both groups is 100%, however, due to hook-wire dislodgement, the success rate in the VATS operation field of the hook-wire group (95.6%) is lower than that of the ICG group (100%), with no significant difference(p=0.056). The overall complication rate of the hook-wire group (37.0%) is significantly higher than the ICG group (35.4%) (p=0.038). The mean respiratory pain score of the hook-wire group is 3.70 +/- 1.25, which is significantly higher than that of the ICG group (2.85 +/- 1.05) (p<0.001). Conclusions ICG composed with contrast mixture are superior to the conventional hook-wire preoperative lung nodule localization procedure, with a lower complication rate, lower pain score, and relatively higher success rate. ICG is a promising alternative method for pulmonary nodule preoperative localization.
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页数:7
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