Pulsatile blood flow and gas exchange across a cylindrical fiber array

被引:8
作者
Chan, Kit Yan [1 ]
Fujioka, Hideki
Hirshl, Ronald B.
Bartlett, Robert H.
Grotberg, James B.
机构
[1] Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Dept Surg, Ann Arbor, MI 48109 USA
来源
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME | 2007年 / 129卷 / 05期
关键词
pulsatile flow; blood; gas transfer; cylinder array; artificial lung;
D O I
10.1115/1.2768105
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
The pulsatile blood flow and gas transport of oxygen and carbon dioxide through a cylindrical array of microfibers are numerically simulated. Blood is modeled as a homogeneous Casson fluid, and hemoglobin molecules in blood are assumed to be in local equilibrium with oxygen and carbon dioxide. It is shown that flow pulsatility, enhances gas transport and the amount of gas exchange is sensitive to the blood flow field across the fibers. The steady Sherwood number dependence on Reynolds number was shown to have a linear relation consistent with experimental findings. For most cases, an enhancement in gas transport is accompanied with an increase inflow resistance. Maximum local shear stress is provided as a possible indicator of thrombosis, and the computed shear stress is shown to be below the threshold value for thrombosis formation for all cases evaluated.
引用
收藏
页码:676 / 687
页数:12
相关论文
共 29 条
[1]   COMPUTATIONALLY 2-DIMENSIONAL FINITE-DIFFERENCE MODEL FOR HOLLOW-FIBER BLOOD-GAS EXCHANGE DEVICES [J].
BAKER, DA ;
HOLTE, JE ;
PATANKAR, SV .
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING, 1991, 29 (05) :482-488
[2]   Pulsatile flow and mass transport over an array of cylinders: Gas transfer in a cardiac-driven artificial lung [J].
Chan, KY ;
Fujioka, H ;
Bartlett, RH ;
Hirschl, RB ;
Grotberg, JB .
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 2006, 128 (01) :85-96
[3]  
CHOW TW, 1992, BLOOD, V80, P113
[4]   Blood HbO2 and HbCO2 dissociation curves at varied O2, CO2, pH, 2,3-DPG and temperature levels [J].
Dash, RK ;
Bassingthwaighte, JB .
ANNALS OF BIOMEDICAL ENGINEERING, 2004, 32 (12) :1676-1693
[5]   Hydrodynamic characteristics of artificial lungs [J].
Dierickx, PW ;
De Somer, F ;
De Wachter, DS ;
Van Nooten, G ;
Verdonck, PR .
ASAIO JOURNAL, 2000, 46 (05) :532-535
[6]   Mass transfer characteristics of artificial lungs [J].
Dierickx, PW ;
De Wachter, DS ;
De Somer, F ;
Van Nooten, G ;
Verdonck, PR .
ASAIO JOURNAL, 2001, 47 (06) :628-633
[7]   Two-dimensional finite element model for oxygen transfer in cross-flow hollow fiber membrane artificial lungs [J].
Dierickx, PW ;
de Wachter, DS ;
Verdonck, PR .
INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS, 2001, 24 (09) :628-635
[8]   Blood flow around hollow fibers [J].
Dierickx, PWT ;
De Wachter, D ;
Verdonck, PR .
INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS, 2000, 23 (09) :610-617
[9]   AN INTRAPLEURAL LUNG PROSTHESIS - RATIONALE, DESIGN, AND TESTING [J].
FAZZALARI, FL ;
BARTLETT, RH ;
BONNELL, MR ;
MONTOYA, JP .
ARTIFICIAL ORGANS, 1994, 18 (11) :801-805
[10]   Effects of blood flow pulse frequency on mass transfer efficiency of a commercial hollow fibre oxygenator [J].
Fiore, GB ;
Pennati, G ;
Inzoli, F ;
Mastrantonio, F ;
Galavotti, D .
INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS, 1998, 21 (09) :535-541