Genetic variation and human aging: Progress and prospects

被引：25
作者：
Melzer, David [1 ]
Hurst, Alison J. [1 ]
Frayling, Tim [1 ]
机构：
[1] Univ Exeter, Peninsula Med Sch, Exeter EX2 5DW, Devon, England
来源：
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES | 2007年 / 62卷 / 03期
关键词：
ESTER TRANSFER PROTEIN; I-CONVERTING-ENZYME; HUMAN LONGEVITY; BIOLOGICAL AGE; GRIP STRENGTH; DANISH TWINS; POLYMORPHISM; ASSOCIATION; HERITABILITY; LIFE;
D O I：
10.1093/gerona/62.3.301
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
The genetics of aging has seen extraordinary progress over the last few decades, with animal models suggesting key roles for a number of metabolic pathways. However, humans outlive laboratory models many times over, and only evidence from humans can ultimately identify the drivers of human aging. In this article we thematically review progress in identifying human genetic variants associated with longevity. We also look at the bigger picture of progress in identifying genetic associates of disease and functioning and healthy aging in older people. Although much of the existing evidence is fragmentary, recent exciting findings and robust methods are taking the field rapidly forward.
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收藏
页码：301 / 307
页数：7
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