Hip2 interacts with cyclin B1 and promotes its degradation through the ubiquitin proteasome pathway

被引：13

作者：

Bae, Yoonhee ^{[1
]}

Choi, Dongwon ^{[1
]}

Rhim, Hyangshuk ^{[2
]}

Kang, Seongman ^{[1
]}

机构：

[1] Korea Univ, Grad Sch Life Sci & Biotechnol, Seoul 136701, South Korea

[2] Catholic Univ Korea, Coll Med, Res Inst Mol Genet, Seoul 137701, South Korea

来源：

FEBS LETTERS | 2010年 / 584卷 / 22期

关键词：

Hip2; Cyclin B1; Ubiquitination; Apoptosis; CONJUGATING ENZYME; CHAIN SYNTHESIS; EXPRESSION; APOPTOSIS; DESTRUCTION; SYSTEM; CELL;

D O I：

10.1016/j.febslet.2010.10.016

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hip2, a ubiquitin conjugating enzyme, is involved in the suppression of cell death. The present study revealed that Hip2 regulates the stability of the apoptotic and cell cycle regulator cyclin B1. Hip2 was found to interact with cyclin B1 to promote its degradation through the ubiquitin proteasome pathway. As a result, Hip2 significantly blocked cell death induced by the cyclin B1 protein, suggesting that Hip2 is involved in the regulation of cyclin B1-mediated cell death. Structured summary: MINT-8045218, MINT-8045231: Hip2 (uniprotkb:P61086) physically interacts (MI:0915) with cyclin-B1 (uniprotkb:P14635) by pull down (MI: 0096) (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：4505 / 4510

页数：6

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