Treating Steroid Refractory Intestinal Acute Graft-vs.-Host Disease With Fecal Microbiota Transplantation: A Pilot Study

被引：97
作者：
Qi, Xiaofei [1 ]
Li, Xuewei [1 ]
Zhao, Ye [1 ]
Wu, Xiaojin [1 ]
Chen, Feng [1 ]
Ma, Xiao [1 ]
Zhang, Faming [2 ]
Wu, Depei [1 ]
机构：
[1] Soochow Univ, Affiliated Hosp 1, Dept Hematol, Suzhou, Peoples R China
[2] Nanjing Med Univ, Affiliated Hosp 2, Med Ctr Digest Dis, Nanjing, Jiangsu, Peoples R China
来源：
FRONTIERS IN IMMUNOLOGY | 2018年 / 9卷
关键词：
fecal microbiota transplantations; refractory gastrointestinal; graft-vs.-host disease; diarrhea; a pilot study; STEM-CELL TRANSPLANTATION; MARROW TRANSPLANTATION; GUT; DIVERSITY; TRACT;
D O I：
10.3389/fimmu.2018.02195
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Patients with steroid refractory gastrointestinal (GI) tract graft- vs.-host disease (GvHD) face a poor prognosis and limited therapeutic options. To accurately assess the efficacy and safety of fecal microbiota transplantation (FMT) in treating steroid refractory GI tract GvHD, we conducted a pilot study involving eight patients. Having received FMTs, all patients' clinical symptoms relieved, bacteria enriched, and microbiota composition reconstructed. Compared to those who did not receive FMT, these eight patients achieved a higher progression-free survival. FMT can serve as a therapeutic option for GI tract aGVHD, but its effectiveness and safety need further evaluations.
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页数：7
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