Emerging Benefits: Pathophysiological Functions and Target Drugs of the Sigma-1 Receptor in Neurodegenerative Diseases

被引：39
作者：
Wu, Ning-hua [1 ,2 ]
Ye, Yu [1 ]
Wan, Bin-bin [1 ]
Yu, Yuan-dong [3 ]
Liu, Chao [1 ]
Chen, Qing-jie [1 ]
机构：
[1] Hubei Univ Sci & Technol, Hubei Key Lab Diabet & Angiopathy, Xianning 437000, Hubei, Peoples R China
[2] Hubei Univ Sci & Technol, Basic Med Coll, Xianning 437000, Hubei, Peoples R China
[3] Hubei Univ Med, Renmin Hosp, Dept Oncol, Shiyan 442000, Hubei, Peoples R China
来源：
MOLECULAR NEUROBIOLOGY | 2021年 / 58卷 / 11期
基金：
中国国家自然科学基金;
关键词：
Sigma-1; receptor; MAM; Neurodegenerative; SIGMAR1; Target drugs; ENDOPLASMIC-RETICULUM; NEUROTROPHIC FACTOR; MOUSE MODEL; PAIN HYPERSENSITIVITY; NEUROPATHIC PAIN; BRAIN PLASTICITY; RAT MODEL; ACTIVATION; PATHWAY; DYSFUNCTION;
D O I：
10.1007/s12035-021-02524-5
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The sigma-1 receptor (Sig-1R) is encoded by the SIGMAR1 gene and is a nonopioid transmembrane receptor located in the mitochondrial-associated endoplasmic reticulum membrane (MAM). It helps to locate endoplasmic reticulum calcium channels, regulates calcium homeostasis, and acts as a molecular chaperone to control cell fate and participate in signal transduction. It plays an important role in protecting neurons through a variety of signaling pathways and participates in the regulation of cognition and motor behavior closely related to neurodegenerative diseases. Based on its neuroprotective effects, Sig-1R has now become a breakthrough target for alleviating Alzheimer's disease and other neurodegenerative diseases. This article reviews the most cutting-edge research on the function of Sig-1R under normal or pathologic conditions and target drugs of the sigma-1 receptor in neurodegenerative diseases.
引用
收藏
页码：5649 / 5666
页数：18
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