Emerging Benefits: Pathophysiological Functions and Target Drugs of the Sigma-1 Receptor in Neurodegenerative Diseases

被引：39

作者：

Wu, Ning-hua ^{[1
,2
]}

Ye, Yu ^{[1
]}

Wan, Bin-bin ^{[1
]}

Yu, Yuan-dong ^{[3
]}

Liu, Chao ^{[1
]}

Chen, Qing-jie ^{[1
]}

机构：

[1] Hubei Univ Sci & Technol, Hubei Key Lab Diabet & Angiopathy, Xianning 437000, Hubei, Peoples R China

[2] Hubei Univ Sci & Technol, Basic Med Coll, Xianning 437000, Hubei, Peoples R China

[3] Hubei Univ Med, Renmin Hosp, Dept Oncol, Shiyan 442000, Hubei, Peoples R China

来源：

MOLECULAR NEUROBIOLOGY | 2021年 / 58卷 / 11期

基金：

中国国家自然科学基金;

关键词：

Sigma-1; receptor; MAM; Neurodegenerative; SIGMAR1; Target drugs; ENDOPLASMIC-RETICULUM; NEUROTROPHIC FACTOR; MOUSE MODEL; PAIN HYPERSENSITIVITY; NEUROPATHIC PAIN; BRAIN PLASTICITY; RAT MODEL; ACTIVATION; PATHWAY; DYSFUNCTION;

D O I：

10.1007/s12035-021-02524-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The sigma-1 receptor (Sig-1R) is encoded by the SIGMAR1 gene and is a nonopioid transmembrane receptor located in the mitochondrial-associated endoplasmic reticulum membrane (MAM). It helps to locate endoplasmic reticulum calcium channels, regulates calcium homeostasis, and acts as a molecular chaperone to control cell fate and participate in signal transduction. It plays an important role in protecting neurons through a variety of signaling pathways and participates in the regulation of cognition and motor behavior closely related to neurodegenerative diseases. Based on its neuroprotective effects, Sig-1R has now become a breakthrough target for alleviating Alzheimer's disease and other neurodegenerative diseases. This article reviews the most cutting-edge research on the function of Sig-1R under normal or pathologic conditions and target drugs of the sigma-1 receptor in neurodegenerative diseases.

引用

页码：5649 / 5666

页数：18

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