Metastatic Colon Cancer Cells Negotiate the Intravasation Notch

被引：16

作者：

Christofori, Gerhard ^{[1
]}

机构：

[1] Univ Basel, Dept Biomed, Inst Biochem & Genet, CH-4058 Basel, Switzerland

来源：

CANCER CELL | 2011年 / 19卷 / 01期

关键词：

D O I：

10.1016/j.ccr.2011.01.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In this issue of Cancer Cell, Sonoshita et al. report that Aes/Grg5 prevents metastasis of colorectal cancer cells by sequestering and inactivating Notch transcriptional effectors in distinct nuclear foci. Loss of Aes/Grg5 in invasive cancer cells where Notch is activated by stroma-expressed ligands promotes invasion, transendothelial migration, intravasation, and metastasis.

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页码：6 / 8

页数：3

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