CD5 negative B-cell chronic lymphocytic leukemia: Clinical and biological features of 42 cases

被引:30
|
作者
Cartron, G [1 ]
Linassier, C [1 ]
Bremond, JL [1 ]
Desablens, B [1 ]
Georget, MT [1 ]
Fimbel, B [1 ]
Luthier, F [1 ]
Dutel, JL [1 ]
Lamagnere, JP [1 ]
Colombat, P [1 ]
机构
[1] Hop Bretonneau, Tours, France
关键词
chronic lymphocytic leukemia; CD5; negative; splenomegaly; phenotype;
D O I
10.3109/10428199809057600
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Chronic lymphocytic leukemia cell (CLL) usually (95%) express B-phenotype and the CD5 antigen which is usually present on the surface of normal T cells. However, among B CLL, 7 to 20% do not express CD5. The significance of the lack of CD5 expression remains unclear. We reviewed 42 consecutive CD5(-) B CLL seen in three French medical centers from 1985 to 1991 and compared them with 79 CD5(+) B CLL. Immunophenotype studies were performed using indirect immunofluorescence under light microscopy as well as flow cytometry after 1988. B CLL was considered to be CD5 negative when less than 5% of mononuclear cells expressed CD5 after substraction of the number of T-cells, Cases with CD5(-) B CLL had isolated splenomegaly more frequently (p = 2.10(-7)). They frequently expressed a higher level of surface immunoglobulin (S-Ig) or the switch mu/delta phenotype (p = 4.7 10(-2)). The median survival time was not reached but no significant difference between CD5 negative and positive B CLL was observed at the time of our data analysis (p = 0.97). Clinical presentation of CD5(-) B CLL seems to be different from other forms of B CLL. Although, no conclusion can be reached in terms of prognosis, CLL with low expression of CD5 should be regarded as a subtype of CLL with a different clinical presentation than CD5(+) CLL.
引用
收藏
页码:209 / 216
页数:8
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