CABANA trial: "beauty is in the eye of the beholder"

被引：2

作者：

Briceno, David ^{[1
]}

Mohanty, Prasant ^{[2
]}

Di Biase, Luigi ^{[1
,2
]}

Romero, Jorge ^{[1
]}

Della Rocca, Domenico Giovanni ^{[2
]}

Trivedi, Chintan ^{[2
]}

Mohanty, Sanghamitra ^{[2
]}

Natale, Andrea ^{[2
]}

机构：

[1] Montefiore Med Ctr, Albert Einstein Canc Ctr, Montefiore Einstein Ctr Heart & Vasc Care, 111 East 210th St Bronx, Bronx, NY 10467 USA

[2] St Davids Med Ctr, Texas Cardiac Arrhythmia Inst, Austin, TX 78705 USA

来源：

JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY | 2020年 / 57卷 / 01期

关键词：

Ablation; Atrila fibrillation; Mortality; Outcomes; RANDOMIZED CLINICAL-TRIALS; COMPOSITE END-POINTS; TO-TREAT ANALYSIS;

D O I：

10.1007/s10840-019-00604-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The CABANA trial reported that catheter ablation, when compared with drug therapy, did not significantly reduce the primary composite end point of death, disabling stroke, serious bleeding, or cardiac arrest in patients with atrial fibrillation. Despite multiple limitations in study design, the CABANA trial still confirmed that catheter ablation of atrial fibrillation led to clinically important and significant improvements in quality of life at 12 months without increasing the risk of complications.

引用

页码：1 / 3

页数：3

共 10 条

[1] On estimating treatment effects under non-compliance in randomized clinical trials: Are intent-to-treat or instrumental variables analyses perfect solutions? [J].

Bang, Heejung ;

Davis, Clarence E. .

STATISTICS IN MEDICINE, 2007, 26 (05) :954-964

[2]

Calkins H, 2018, EUROPACE, V20, pE1, DOI [10.1093/europace/eux274, 10.1093/europace/eux275, 10.1016/j.hrthm.2017.05.012]

[3] A Comparison of Methods for Estimating the Causal Effect of a Treatment in Randomized Clinical Trials Subject to Noncompliance [J].

Little, Roderick J. ;

Long, Qi ;

Lin, Xihong .

BIOMETRICS, 2009, 65 (02) :640-649

[4] Effect of Catheter Ablation vs Medical Therapy on Quality of Life Among Patients With Atrial Fibrillation The CABANA Randomized Clinical Trial [J].

Mark, Daniel B. ;

Anstrom, Kevin J. ;

Sheng, Shubin ;

Piccini, Jonathan P. ;

Baloch, Khaula N. ;

Monahan, Kristi H. ;

Daniels, Melanie R. ;

Bahnson, Tristram D. ;

Poole, Jeanne E. ;

Rosenberg, Yves ;

Lee, Kerry L. ;

Packer, Douglas L. ;

Robb, Richard A. ;

Rettmann, Maryam E. ;

Martinez, Beth ;

Mascette, Alice ;

Jeffries, Neal ;

Mitchell, L. Brent ;

Flaker, Greg G. ;

Al-Khalidi, Hussein R. ;

Silverstein, Adam ;

Ellis, Alicia ;

Ussery, Sheri A. ;

Moretz, Kathleen L. ;

Hagen, Sarah ;

Anstrom, Kevin ;

Baloch, Khaula ;

Liu, Diane M. ;

Blount, Janet ;

Cowper, Patricia ;

Knight, David ;

O'Neal, Elizabeth F. ;

Holmes, David R., III ;

Breen, Jerome ;

Wilber, David ;

Reiffel, James ;

Kowey, Peter ;

Naccarelli, Gerald ;

DiMarco, John P. ;

Davies, D. Wyn ;

Cappato, Riccardo ;

Kalman, Jon M. ;

Kuck, Karl-Heinz ;

Hindricks, Gerhardt ;

Calkins, Hugh ;

Stevenson, William G. ;

Buxton, Alfred ;

Curtis, Anne B. ;

Davis, Barry R. ;

Ulrich, Connie M. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2019, 321 (13) :1275-1285

[5] Understanding the Use of Composite Endpoints in Clinical Trials [J].

Mccoy, C. Eric .

WESTERN JOURNAL OF EMERGENCY MEDICINE, 2018, 19 (04) :631-634

[6] Validity of composite end points in clinical trials [J].

Montori, VM ;

Permanyer-Miralda, G ;

Ferreira-González, I ;

Busse, JW ;

Pacheco-Huergo, V ;

Bryant, D ;

Alonso, J ;

Akl, EA ;

Domingo-Salvany, A ;

Mills, E ;

Wu, P ;

Schünemann, HJ ;

Jaeschke, R ;

Guyatt, GH .

BMJ-BRITISH MEDICAL JOURNAL, 2005, 330 (7491) :594-596

[7] Effect of Catheter Ablation vs Antiarrhythmic Drug Therapy on Mortality, Stroke, Bleeding, and Cardiac Arrest Among Patients With Atrial Fibrillation The CABANA Randomized Clinical Trial [J].

Packer, Douglas L. ;

Mark, Daniel B. ;

Robb, Richard A. ;

Monahan, Kristi H. ;

Bahnson, Tristram D. ;

Poole, Jeanne E. ;

Noseworthy, Peter A. ;

Rosenberg, Yves D. ;

Jeffries, Neal ;

Mitchell, L. Brent ;

Flaker, Greg C. ;

Pokushalov, Evgeny ;

Romanov, Alexander ;

Bunch, T. Jared ;

Noelker, Georg ;

Ardashev, Andrey ;

Revishvili, Amiran ;

Wilber, David J. ;

Cappato, Riccardo ;

Kuck, Karl-Heinz ;

Hindricks, Gerhard ;

Davies, D. Wyn ;

Kowey, Peter R. ;

Naccarelli, Gerald V. ;

Reiffel, James A. ;

Piccini, Jonathan P. ;

Silverstein, Adam P. ;

Al-Khalidi, Hussein R. ;

Lee, Kerry L. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2019, 321 (13) :1261-1274

[8] INTENTION-TO-TREAT ANALYSIS AND THE GOALS OF CLINICAL-TRIALS [J].

SHEINER, LB ;

RUBIN, DB .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 1995, 57 (01) :6-15

[9] The Intention-to-Treat Analysis Is Not Always the Conservative Approach [J].

Shrier, Ian ;

Verhagen, Evert ;

Stovitz, Steven D. .

AMERICAN JOURNAL OF MEDICINE, 2017, 130 (07) :867-871

[10] Estimating treatment effects in randomised controlled trials with non-compliance: a simulation study [J].

Ye, Chenglin ;

Beyene, Joseph ;

Browne, Gina ;

Thabane, Lehana .

BMJ OPEN, 2014, 4 (06)

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