The Mechanism Action of German Chamomile (Matricaria recutita L.) in the Treatment of Eczema: Based on Dose-Effect Weight Coefficient Network Pharmacology

被引：25

作者：

Wang, Wenfei ^{[1
]}

Wang, Yichun ^{[1
]}

Zou, Junbo ^{[1
,2
]}

Jia, Yanzhuo ^{[1
]}

Wang, Yao ^{[1
]}

Li, Jia ^{[1
]}

Wang, Changli ^{[1
,2
]}

Sun, Jing ^{[1
,2
]}

Guo, Dongyan ^{[1
,2
]}

Wang, Fang ^{[3
]}

Wu, Zhenfeng ^{[3
]}

Yang, Ming ^{[3
]}

Wu, Lei ^{[4
]}

Zhang, Xiaofei ^{[1
,2
,3
]}

Shi, Yajun ^{[1
,2
]}

机构：

[1] Shaanxi Univ Chinese Med, Coll Pharm, Dept Pharmaceut, Xianyang, Peoples R China

[2] Shaanxi Univ Chinese Med, Dept Pharmaceut, Key Lab Basic & New Drug Res Tradit Chinese Med, Xianyang, Peoples R China

[3] Jiangxi Univ Chinese Med, Key Lab Modern Preparat Tradit Chinese Med, Minist Educ, Dept Pharmaceut, Nanchang, Jiangxi, Peoples R China

[4] Heinan Feinari Aromat Biotechnol Co Ltd, Zhumadian, Peoples R China

来源：

FRONTIERS IN PHARMACOLOGY | 2021年 / 12卷

基金：

中国国家自然科学基金;

关键词：

German chamomile; eczema; weight coefficient; molecular docking; mechanism verification;

D O I：

10.3389/fphar.2021.706836

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

To determine the active ingredients in German chamomile volatile oil and the mechanism of action in the treatment of eczema, this study used two parameters (ingredient content and oil-water partition coefficient) and established a new network pharmacology method based on the dose-effect weight coefficient. Through the new network pharmacology method, we found that German chamomile volatile oil regulated T-cell lymphatic subpopulations to inhibit the Th17 cell differentiation signaling pathway. This resulted in a reduction of interleukin 17 (IL-17), thereby inhibiting the activation of the nuclear factor kappa beta (NF-kappa B) and MAPK pathways, decreasing the secretion of the pro-inflammatory factors (tumor necrosis factor alpha (TNF-alpha) and interleukin 6 (IL-6)), and reducing inflammation. In this study, a new dose-effect relationship synergistic network pharmacology method was established to provide a new method for the screening of effective ingredients and pathways of drugs, and to provide a basis for the follow-up studies of German chamomile volatile oil in the treatment of eczema.

引用

页数：13

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