The evolution of wireless systems has taken place in a remarkably short time, offering incredible technological advances that will change the way how people communicate and interact with each other, These advances have come in several generations, Every generation to standards, capabilities and new techniques. Fifth-generation wireless networks face a variety of challenges in supporting large-scale heterogeneous networks. For this, new multi-carrier modulations and their associations with multi-antenna systems have been developed to support these changes. In this context, this article presents a comparative study of two systems, MIMO- FBMC/OQAM (Multiple-Input Multiple-Output - Filter Bank Multi-Carrier and Offset Quadrature Amplitude Modulation) and MIMO-UFMC (Universal Filtered Multi-Carrier) with different equalization techniques such as Zero Forcing (ZF), Minimum Mean Square Error (MMSE) and Maximal Ratio Combining (MRC). These two modulation techniques are evaluated in a Rayleigh channel in terms of signal-to-noise ratio (SNR) and bit error ratio (BER). The simulation is performed, and the mathematical analysis confirms that the performance of the MIMO-FBMC / OQAM technique with the MRC equalizer is a better choice than the MIMO-UFMC to suppress any inter-symbol interference (ISI) and reduces the total noise power.