Synthesis of pyrinidine-2,4(1H,3H)-dione derivatives containing N-alkyl substituents

6-Methyluracil derivatives containing a gem-dichlorocyclopropane and a 1,3-dioxolane fragments were synthesized for the first time. The condensation of 6-methyluracil with chloromethyl derivatives gives a mixture of N-1- and N-3-monosubstituted products, and the profound N-alkylation of this compound provides disubstituted uracils. The structure of the synthesized compounds was studied by H-1 and C-13 NMR spectroscopy and their relative antioxidant activity was evaluated by luminol-dependent chemiluminescence measurements.