Can Melatonin Be a Potential "Silver Bullet" in Treating COVID-19 Patients?
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作者:
Cardinali, Daniel P.
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Pontificia Univ Catolica Argentina, Fac Med Sci, RA-1007 Buenos Aires, DF, ArgentinaPontificia Univ Catolica Argentina, Fac Med Sci, RA-1007 Buenos Aires, DF, Argentina
Cardinali, Daniel P.
[1
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Brown, Gregory M.
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Pandi-Perumal, Seithikurippu R.
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Somnogen Canada Inc, Coll St, Toronto, ON M6H 1C5, CanadaPontificia Univ Catolica Argentina, Fac Med Sci, RA-1007 Buenos Aires, DF, Argentina
Pandi-Perumal, Seithikurippu R.
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[1] Pontificia Univ Catolica Argentina, Fac Med Sci, RA-1007 Buenos Aires, DF, Argentina
The therapeutic potential of melatonin as a chronobiotic cytoprotective agent to counteract the consequences of COVID-19 infections has been advocated. Because of its wide-ranging effects as an antioxidant, anti-inflammatory, and immunomodulatory compound, melatonin could be unique in impairing the consequences of SARS-CoV-2 infection. Moreover, indirect evidence points out to a possible antiviral action of melatonin by interfering with SARS-CoV-2/angiotensin-converting enzyme 2 association. Melatonin is also an effective chronobiotic agent to reverse the circadian disruption of social isolation and to control delirium in severely affected patients. As a cytoprotector, melatonin serves to combat several comorbidities such as diabetes, metabolic syndrome, and ischemic and non-ischemic cardiovascular diseases, which aggravate COVID-19 disease. In view of evidence on the occurrence of neurological sequels in COVID-19-infected patients, another putative application of melatonin emerges based on its neuroprotective properties. Since melatonin is an effective means to control cognitive decay in minimal cognitive impairment, its therapeutic significance for the neurological sequels of SARS-CoV-2 infection should be considered. Finally, yet importantly, exogenous melatonin can be an adjuvant capable of augmenting the efficacy of anti-SARS-CoV-2 vaccines. We discuss in this review the experimental evidence suggesting that melatonin is a potential "silver bullet" in the COVID 19 pandemic.
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King Saud Univ, Coll Sci, Dept Chem, POB 2455, Riyadh 11451, Saudi Arabia
Ibb Univ, Coll Sci, Dept Chem, POB 70270, Ibb, YemenKing Saud Univ, Coll Sci, Dept Chem, POB 2455, Riyadh 11451, Saudi Arabia
Al-Zaqri, Nabil
Pooventhiran, T.
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St Berchmans Coll Autonomous, Dept Chem, Changanassery, Kerala, IndiaKing Saud Univ, Coll Sci, Dept Chem, POB 2455, Riyadh 11451, Saudi Arabia
Pooventhiran, T.
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Alsalme, Ali
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Warad, Ismail
John, Athira M.
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CHRIST Deemed Be Univ, Dept Chem, Bangalore, Karnataka, IndiaKing Saud Univ, Coll Sci, Dept Chem, POB 2455, Riyadh 11451, Saudi Arabia
John, Athira M.
Thomas, Renjith
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St Berchmans Coll Autonomous, Dept Chem, Changanassery, Kerala, IndiaKing Saud Univ, Coll Sci, Dept Chem, POB 2455, Riyadh 11451, Saudi Arabia
机构:
QIMR Berghofer Med Res Inst, Oncol & Cellular Immunol Lab, Herston, Qld, AustraliaQIMR Berghofer Med Res Inst, Oncol & Cellular Immunol Lab, Herston, Qld, Australia
Bald, Tobias
Krummel, Matthew F.
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Univ Calif San Francisco, Dept Pathol, ImmunoX Initiat, San Francisco, CA 94140 USA
Univ Calif San Francisco, Parker Inst Canc Immunotherapy, San Francisco, CA 94143 USAQIMR Berghofer Med Res Inst, Oncol & Cellular Immunol Lab, Herston, Qld, Australia
Krummel, Matthew F.
Smyth, Mark J.
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QIMR Berghofer Med Res Inst, Immunol Canc & Infect Lab, Herston, Qld, AustraliaQIMR Berghofer Med Res Inst, Oncol & Cellular Immunol Lab, Herston, Qld, Australia
Smyth, Mark J.
Barry, Kevin C.
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Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Translat Res Program, 1124 Columbia St, Seattle, WA 98104 USAQIMR Berghofer Med Res Inst, Oncol & Cellular Immunol Lab, Herston, Qld, Australia
机构:
King Saud Univ, Coll Sci, Dept Chem, POB 2455, Riyadh 11451, Saudi Arabia
Ibb Univ, Coll Sci, Dept Chem, POB 70270, Ibb, YemenKing Saud Univ, Coll Sci, Dept Chem, POB 2455, Riyadh 11451, Saudi Arabia
Al-Zaqri, Nabil
Pooventhiran, T.
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St Berchmans Coll Autonomous, Dept Chem, Changanassery, Kerala, IndiaKing Saud Univ, Coll Sci, Dept Chem, POB 2455, Riyadh 11451, Saudi Arabia
Pooventhiran, T.
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Alsalme, Ali
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Warad, Ismail
John, Athira M.
论文数: 0引用数: 0
h-index: 0
机构:
CHRIST Deemed Be Univ, Dept Chem, Bangalore, Karnataka, IndiaKing Saud Univ, Coll Sci, Dept Chem, POB 2455, Riyadh 11451, Saudi Arabia
John, Athira M.
Thomas, Renjith
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机构:
St Berchmans Coll Autonomous, Dept Chem, Changanassery, Kerala, IndiaKing Saud Univ, Coll Sci, Dept Chem, POB 2455, Riyadh 11451, Saudi Arabia
机构:
QIMR Berghofer Med Res Inst, Oncol & Cellular Immunol Lab, Herston, Qld, AustraliaQIMR Berghofer Med Res Inst, Oncol & Cellular Immunol Lab, Herston, Qld, Australia
Bald, Tobias
Krummel, Matthew F.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Pathol, ImmunoX Initiat, San Francisco, CA 94140 USA
Univ Calif San Francisco, Parker Inst Canc Immunotherapy, San Francisco, CA 94143 USAQIMR Berghofer Med Res Inst, Oncol & Cellular Immunol Lab, Herston, Qld, Australia
Krummel, Matthew F.
Smyth, Mark J.
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h-index: 0
机构:
QIMR Berghofer Med Res Inst, Immunol Canc & Infect Lab, Herston, Qld, AustraliaQIMR Berghofer Med Res Inst, Oncol & Cellular Immunol Lab, Herston, Qld, Australia
Smyth, Mark J.
Barry, Kevin C.
论文数: 0引用数: 0
h-index: 0
机构:
Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Translat Res Program, 1124 Columbia St, Seattle, WA 98104 USAQIMR Berghofer Med Res Inst, Oncol & Cellular Immunol Lab, Herston, Qld, Australia