Dipyrone, a novel anticonvulsant agent? Insights from three experimental epilepsy models

被引:26
作者
Doretto, MC
Garcia-Cairasco, N
Pimenta, NJG
Souza, DA
Tatsuo, MAKF
机构
[1] Univ Fed Minas Gerais, Inst Biol Sci, Dept Physiol & Biophys, BR-31270901 Belo Horizonte, MG, Brazil
[2] Univ Fed Minas Gerais, Inst Biol Sci, Dept Pharmacol, BR-31270901 Belo Horizonte, MG, Brazil
[3] Univ Sao Paulo, Ribeirao Preto Sch Med, Dept Physiol, BR-05508 Sao Paulo, Brazil
关键词
audiogenic kindling; audiogenic seizures; dipyrone; electroshock; epilepsy; postictal analgesia; tail-flick;
D O I
10.1097/00001756-199807130-00048
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
DIPYRONE, a non-steroidal anti-inflammatory agent, was anticonvulsant in three experimental epilepsy models. At a dose of 300 mg/kg i.p., dipyrone blocked the maximal hind limb extension in the electroshock model in Wistar rats, the tonic-clonic component of acute sound-induced seizures and the limbic component of audiogenic kindling in genetically susceptible Wistar-derived rats, all in 100% of the animals. In the electroshock model higher doses (400 and 500 mg/kg) were also effective but lower doses (100 and 200 mg/kg) were not. In this model dipyrone had no effect on the recovery of the righting reflex and intensified the postictal antinociception in a dose-dependent manner. Other non-steroidal anti-inflammatory agents such as indomethacin, diclofenac and aspirin had no anticonvulsant effect in the electroshock-induced seizures. NeuroReport 9: 2415-2419 (C) 1998 Rapid Science Ltd.
引用
收藏
页码:2415 / 2421
页数:7
相关论文
共 23 条
[1]   ACTIVATION OF INHIBITION FROM THE PERIAQUEDUCTAL GRAY-MATTER MEDIATES CENTRAL ANALGESIC EFFECT OF METAMIZOL (DIPYRONE) [J].
CARLSSON, KH ;
HELMREICH, J ;
JURNA, I .
PAIN, 1986, 27 (03) :373-390
[2]   DEPRESSION BY MORPHINE AND THE NON-OPIOID ANALGESIC AGENTS, METAMIZOL (DIPYRONE), LYSINE ACETYLSALICYLATE, AND PARACETAMOL, OF ACTIVITY IN RAT THALAMUS NEURONS EVOKED BY ELECTRICAL-STIMULATION OF NOCICEPTIVE AFFERENTS [J].
CARLSSON, KH ;
MONZEL, W ;
JURNA, I .
PAIN, 1988, 32 (03) :313-326
[3]  
D'amour FE, 1941, J PHARMACOL EXP THER, V72, P74
[4]   TEMPORALSPATIAL PATTERNS OF EXPRESSION OF METALLOTHIONEIN-I AND METALLOTHIONEIN-III AND OTHER STRESS-RELATED GENES IN RAT-BRAIN AFTER KAINIC ACID-INDUCED SEIZURES [J].
DALTON, T ;
PAZDERNIK, TL ;
WAGNER, J ;
SAMSON, F ;
ANDREWS, GK .
NEUROCHEMISTRY INTERNATIONAL, 1995, 27 (01) :59-71
[5]   IS ADENOSINE AN ENDOGENOUS ANTICONVULSANT [J].
DRAGUNOW, M ;
GODDARD, GV ;
LAVERTY, R .
EPILEPSIA, 1985, 26 (05) :480-487
[6]   ADENOSINE - A POTENTIAL MEDIATOR OF SEIZURE ARREST AND POSTICTAL REFRACTORINESS [J].
DURING, MJ ;
SPENCER, DD .
ANNALS OF NEUROLOGY, 1992, 32 (05) :618-624
[7]   ENDOGENOUS OPIOIDS MAY MEDIATE POST-ICTAL BEHAVIORAL DEPRESSION IN AMYGDALOID-KINDLED RATS [J].
FRENK, H ;
ENGEL, J ;
ACKERMANN, RF ;
SHAVIT, Y ;
LIEBESKIND, JC .
BRAIN RESEARCH, 1979, 167 (02) :435-440
[8]   Interleukin-1 alpha in the brain is induced by audiogenic seizure [J].
Gahring, LC ;
White, HS ;
Skradski, SL ;
Carlson, NG ;
Rogers, SW .
NEUROBIOLOGY OF DISEASE, 1997, 3 (04) :263-269
[9]  
Garcia-Cairasco N, 1990, EPILEPSIA, V31, P815
[10]   NEW INSIGHTS INTO BEHAVIORAL-EVALUATION OF AUDIOGENIC-SEIZURES - A COMPARISON OF 2 ETHOLOGICAL METHODS [J].
GARCIACAIRASCO, N ;
DORETTO, MC ;
PRADO, RP ;
JORGE, BPD ;
TERRA, VC ;
OLIVEIRA, JAC .
BEHAVIOURAL BRAIN RESEARCH, 1992, 48 (01) :49-56