Gut microbiota composition during infancy and subsequent behavioural outcomes

被引：71
作者：
Loughman, Amy [1 ]
Ponsonby, Anne-Louise [2 ,8 ]
O'Hely, Martin [1 ,2 ]
Symeonides, Christos [2 ,4 ,5 ]
Collier, Fiona [1 ,2 ,3 ]
Tang, Mimi L. K. [2 ,4 ,5 ]
Carlin, John [2 ,4 ]
Ranganathan, Sarath [2 ,4 ,5 ]
Allen, Katrina [2 ,4 ,5 ]
Pezic, Angela [2 ]
Saffery, Richard [2 ,4 ]
Jacka, Felice [1 ,2 ]
Harrison, Leonard C. [4 ,6 ]
Sly, Peter D. [2 ,7 ]
Vuillermin, Peter [1 ,2 ,3 ]
机构：
[1] Deakin Univ, Geelong, Vic 3220, Australia
[2] Murdoch Childrens Res Inst, Parkville, Vic 3052, Australia
[3] Barwon Hlth, Geelong, Vic 3220, Australia
[4] Univ Melbourne, Parkville, Vic 3052, Australia
[5] Royal Childrens Hosp, Parkville, Vic 3052, Australia
[6] Walter & Eliza Hall Inst Med Res, Parkville, Vic 3052, Australia
[7] Univ Queensland, South Brisbane, Qld 4101, Australia
[8] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Parkville, Vic 3052, Australia
来源：
EBIOMEDICINE | 2020年 / 52卷
基金：
英国医学研究理事会;
关键词：
Infant; Behaviour; Microbiota; Gut-brain axis; DISEASE; EXPOSURE; STRESS; DIET;
D O I：
10.1016/j.ebiom.2020.102640
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Background: Despite intense interest in the relationship between gut microbiota and brain development, longitudinal data from human studies are lacking. This study aimed to investigate the relationship between the composition of gut microbiota during infancy and subsequent behavioural outcomes. Methods: A subcohort of 201 children with behavioural outcome measures was identified within a longitudinal, Australian birth-cohort study. The faecal microbiota were analysed at 1, 6, and 12 months of age. Behavioural outcomes were measured at 2 years of age. Findings: In an unselected birth cohort, we found a clear association between decreased normalised abundance of Prevotella in faecal samples collected at 12 months of age and increased behavioural problems at 2 years, in particular Internalizing Problem scores. This association appeared independent of multiple potentially confounding variables, including maternal mental health. Recent exposure to antibiotics was the best predictor of decreased Prevotella. Interpretation: Our findings demonstrate a strong association between the composition of the gut microbiota in infancy and subsequent behavioural outcomes; and support the importance of responsible use of antibiotics during early life. (C) 2020 Published by Elsevier B.V.
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页数：8
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